Improving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomes

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dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authoridUner, Burcu/0000-0003-4691-0432
dc.authoridErgin, Ahmet Dogan/0000-0002-9387-0085
dc.authoridBenetti, Camillo/0000-0002-3309-6761
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.authorwosidUner, Burcu/GPG-1519-2022
dc.authorwosidErgin, Ahmet Dogan/AAO-1876-2021
dc.authorwosidDemirbağ, Çağlar/KII-5788-2024
dc.contributor.authorErgin, Ahmet Dogan
dc.contributor.authorUner, Burcu
dc.contributor.authorBalcib, Sencan
dc.contributor.authorDemirbag, Caglar
dc.contributor.authorBenetti, Camillo
dc.contributor.authorOltulu, Cagatay
dc.date.accessioned2024-06-12T11:12:57Z
dc.date.available2024-06-12T11:12:57Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCoenzyme Q10 (CoQ10) is a fat-soluble vitamin-with a benzoquinone-like structure. CoQ10 plays a role in membrane stability, energy conversion, and ATP production. It is also one of the important antioxidants in the body. The bioavailability of exogenous CoQ10 is extremely low due to its poor aqueous solubility and large molecular mass.In this study, mixed proniosomal drug delivery systems have been used to increase solubility and bioavailability of CoQ10. Arginine (semi-essential amino acid) was incorporated in the formulation composition to achieve higher efficacy by boosting nitric oxide presence, endothelial dysfunction, and cellular uptake.Proniosomes were investigated in terms of particle size, polydispersity index, zeta potential, encapsulation efficiency, and process yield, and optimization studies were carried on by utilizing STATISTICA 8.0 software considering dependent factors (carrier amount, drug amount, and surfactant ratio). Optimum proniosome formulation (particle size 187.5 +/- 16.35 nm, zeta potential: -44.7 +/- 12.8 mV, encapsulation efficiency 99.05 +/- 0.30%, and product yield: 90.55%) was evaluated for thermal analysis, in-vitro drug release using microcentrifuge method. In-vitro cytotoxicity studies of proniosomes were performed on intestinal Epithelial Cells (Cellartis (R), ChiPSC18) and no cytotoxic effects was seen during the 72 h. Besides, anti Alzheimer effect was investigated on APPSL-GFP lentivirus-infected human neural cells (APPSL-GFP-l-HNC) and Alzheimer biomarkers (p-tau181 and p-tau217).While CoQ10's relative bioavailability was statistically increased by proniosome compared to CoQ10 suspension (p<0.01, Grubb test). PK parameters of proniosome formulation, obtained with non-compartmental modeling, were fitting to the data (R-2=0.956 +/- 0.026).The study results proved that proniosomal formulation has a high potential drug delivery system for both increasing bioavailability and anti-Alzheimer effect of CoQ10.(c) 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.xphs.2023.07.020
dc.identifier.endpage2932en_US
dc.identifier.issn0022-3549
dc.identifier.issn1520-6017
dc.identifier.issue11en_US
dc.identifier.pmid37506768en_US
dc.identifier.scopus2-s2.0-85167837830en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2921en_US
dc.identifier.urihttps://doi.org/10.1016/j.xphs.2023.07.020
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23371
dc.identifier.volume112en_US
dc.identifier.wosWOS:001101476200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProniosomeen_US
dc.subjectCoenzyme Q10en_US
dc.subjectSlurry Methoden_US
dc.subjectPharmacokineticen_US
dc.subjectBioavailabilityen_US
dc.subjectIn-Vitro Dissolutionen_US
dc.subjectDrug-Deliveryen_US
dc.subjectCandesartan Cilexetilen_US
dc.subjectVesicles Niosomesen_US
dc.subjectOral Deliveryen_US
dc.subjectModelen_US
dc.subjectSolubilityen_US
dc.subjectOptimizationen_US
dc.subjectReleaseen_US
dc.subjectEncapsulationen_US
dc.titleImproving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomesen_US
dc.typeArticleen_US

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