The effects of topical treatment with curcumin on burn wound healing in rats

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dc.authoridOzen, Oguz Aslan/0000-0003-2521-0031
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidOzen, Oguz Aslan/AHE-6215-2022
dc.contributor.authorKulac, Mustafa
dc.contributor.authorAktas, Cevat
dc.contributor.authorTulubas, Feti
dc.contributor.authorUygur, Ramazan
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorCeber, Mehmet
dc.date.accessioned2024-06-12T10:55:26Z
dc.date.available2024-06-12T10:55:26Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study was designed to determine the role of topical treatment with curcumin (Cur) on burn wound healing in rats. The Wistar-albino rats were randomly allotted into one of three experimental groups: 4th, 8th and 12th day (post burn) and all groups include subgroups which Burn and Burn + Cur. Each group contains 12 animals. Burn wounds were made on the back of rat and Cur was administered topically. At the end of the study, all animals were sacrificed and the wound tissues removed for analyse to biochemical and histopathological changes. There was a significant increase in the hydroxyproline levels in the skin of the Cur groups. Cur treated wounds were found to heal much faster as indicated by improved rates of inflammatory cells, collagen deposition, angiogenesis, granulation tissue formation and epithelialization which were also confirmed by histopathological and biochemical examinations. Our data also indicate that there is a rise in the expression of proliferating cell nuclear antigen in skin tissues of Cur-treated rats in the Burn group. The results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing.en_US
dc.identifier.doi10.1007/s10735-012-9452-9
dc.identifier.endpage90en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue1en_US
dc.identifier.pmid23054142en_US
dc.identifier.scopus2-s2.0-84872597381en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-012-9452-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19413
dc.identifier.volume44en_US
dc.identifier.wosWOS:000313495800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurn Wound Healingen_US
dc.subjectCurcuminen_US
dc.subjectPCNAen_US
dc.subjectHydroxyprolineen_US
dc.subjectRaten_US
dc.subjectThermal-Injuryen_US
dc.subjectInduced Apoptosisen_US
dc.subjectOxidative Damageen_US
dc.subjectNitric-Oxideen_US
dc.subjectSkinen_US
dc.subjectRepairen_US
dc.subjectLongaen_US
dc.subjectCellsen_US
dc.subjectMiceen_US
dc.subjectHydroxyprolineen_US
dc.titleThe effects of topical treatment with curcumin on burn wound healing in ratsen_US
dc.typeArticleen_US

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