Phenolic compounds from Trifolium echinatum Bieb. and investigation of their tyrosinase inhibitory and antioxidant activities

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dc.authoridSABUDAK, Temine/0000-0003-4384-4265
dc.authoridTopcu, Gulacti/0000-0002-7946-6545
dc.authoridÖztürk, Mehmet/0000-0001-8932-4535
dc.authoridTopcu, Gulacti/0000-0002-7946-6545;
dc.authorwosidSABUDAK, Temine/AAG-6784-2019
dc.authorwosidTopcu, Gulacti/C-8344-2015
dc.authorwosidÖztürk, Mehmet/W-4649-2017
dc.authorwosidTopcu, Gulacti/AAH-8305-2019
dc.authorwosidÖztürk, Mehmet/JFJ-3399-2023
dc.contributor.authorSabudak, Temine
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorOzturk, Mehmet
dc.contributor.authorTopcu, Gulacti
dc.date.accessioned2024-06-12T11:01:45Z
dc.date.available2024-06-12T11:01:45Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTwo bischromones, 3,3'-dimethoxy-2'-oxychromone (1), 3,3'-dihydroxy-2,2'-oxychromone (2) and a biflavone, 5,7,4',5 '',3''',4''''-hexahydroxy-3 ''-O-beta-glucosyl-3',7 ''-O-biflavone (3) have been isolated from whole plant of Trifolium echinatum Bieb. together with five known fiavonoids. The structures of the compounds were elucidated by 1D and 2D NMR analysis as well as HRESIMS. The isolated compounds were investigated for their antioxidant activity and tyrosinase inhibitory activity. Highly potent inhibition was found for compounds 1 (IC50 = 0.41 mM), 5 (IC50 = 0.47 mM) and 8 (IC50 = 0.45 mM) compared to those of standard tyrosinase inhibitors kojic acid (IC50= 0.67 mM) and L-mimosine (IC50 = 0.64 mM). The antioxidative effect of the extracts was determined by using beta-carotene-linoleic acid, DPPH. scavenging, ABTS(+-) scavenging, and CUPRAC assays. The experimental findings indicated that the compounds 2 and 8 were found to be active in radical scavenging and CUPRAC assays. (C) 2013 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [108T779]en_US
dc.description.sponsorshipWe thank to TUBITAK (The Scientific and Technological Research Council of Turkey) for financial support (project number: 108T779).en_US
dc.identifier.doi10.1016/j.phytochem.2013.08.014
dc.identifier.endpage311en_US
dc.identifier.issn0031-9422
dc.identifier.pmid24070617en_US
dc.identifier.scopus2-s2.0-84888341067en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytochem.2013.08.014
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21002
dc.identifier.volume96en_US
dc.identifier.wosWOS:000328869500031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPhytochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFabaceaeen_US
dc.subjectTrifolium Echinatumen_US
dc.subjectBischromoneen_US
dc.subjectBiflavonoiden_US
dc.subjectTyrosinase Inhibitionen_US
dc.subjectAntioxidant Activityen_US
dc.subjectIdentificationen_US
dc.subjectSpectroscopyen_US
dc.subjectComponentsen_US
dc.subjectPlanten_US
dc.subjectMsen_US
dc.titlePhenolic compounds from Trifolium echinatum Bieb. and investigation of their tyrosinase inhibitory and antioxidant activitiesen_US
dc.typeArticleen_US

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