Prevention of radiation-induced liver and kiney toxicity: a role for amifostine

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidIbis, Kamuran/AAD-1939-2019
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.contributor.authorUguzalp-Kaldir, Mine
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorCosar-Alas, Rusen
dc.contributor.authorCermik, Tevfik Fikret
dc.contributor.authorAltaner, Semsi
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorSaynak, Mert
dc.date.accessioned2024-06-12T10:51:23Z
dc.date.available2024-06-12T10:51:23Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVES To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters. METHODS Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem. RESULTS A clear protective effect of amifostine against radiation-induced late dam age in liver and kidney was found with scintigraphic evaluaticn. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues. CONCLUSION The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.en_US
dc.identifier.endpage117en_US
dc.identifier.issn1300-7467
dc.identifier.issue3en_US
dc.identifier.startpage105en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18352
dc.identifier.volume22en_US
dc.identifier.wosWOS:000439251100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectKidney/Radiation Effectsen_US
dc.subjectLiver/Radiation Effectsen_US
dc.subjectRadiotherapy/Yan Etkien_US
dc.subjectRisk Factorsen_US
dc.subjectToxicityen_US
dc.titlePrevention of radiation-induced liver and kiney toxicity: a role for amifostineen_US
dc.typeArticleen_US

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