Serum Adiponectin Level as a Predictor of Subclinical Cushing's Syndrome in Patients with Adrenal Incidentaloma

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dc.authoridAldemir, Derya Akaydın/0000-0002-8680-6691
dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authoridTütüncü, Neslihan Başçıl/0000-0002-1816-3903
dc.authorwosidAldemir, Derya Akaydın/AAJ-2165-2021
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.authorwosidTütüncü, Neslihan Başçıl/ABG-5027-2020
dc.contributor.authorUnal, Asli Dogruk
dc.contributor.authorAyturk, Semra
dc.contributor.authorAldemir, Derya
dc.contributor.authorTutuncu, Neslihan Bascil
dc.date.accessioned2024-06-12T11:17:46Z
dc.date.available2024-06-12T11:17:46Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSubclinical Cushing's syndrome (SCS) is a condition of slight but chronic cortisol excess in patients with adrenal incidentaloma (AI) without typical signs and symptoms of Cushing's syndrome. Adiponectin has potent roles in modulating energy balance and metabolic homeostasis and acts in opposition to glucocorticoids. This study aimed to evaluate adiponectin level in SCS and nonfunctional AI (NAI) patients and its relation with metabolic parameters. Patients with AI (n = 40) and metabolically healthy controls (n = 30) were included. In AI patients and controls, detailed medical history assessment, physical examinations, anthropometric measurements, and laboratory measurements were performed. Age, body mass index, waist circumference, and lipid profiles were significantly higher and waist-to-hip ratio and adiponectin level were significantly lower in the AI patients than in the controls. The midnight cortisol and urinary free cortisol levels were significantly higher in the SCS patients (n = 8) than in the NAI patients (n = 32). Adiponectin level of the SCS group was significantly lower than those of the NAI and control groups. The sensitivity and specificity for an adiponectin level of <= 13.00 ng/mL in predicting the presence of SCS were 87.5% and 77.4%, respectively. In conclusion, adiponectin is valuable in predicting the presence of SCS in AI patients.en_US
dc.identifier.doi10.1155/2016/8519362
dc.identifier.issn1687-8337
dc.identifier.issn1687-8345
dc.identifier.pmid27656211en_US
dc.identifier.scopus2-s2.0-84987922576en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1155/2016/8519362
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24841
dc.identifier.volume2016en_US
dc.identifier.wosWOS:000383109000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofInternational Journal Of Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascular Risken_US
dc.subjectInsulin Sensitivityen_US
dc.subjectDiagnostic-Criteriaen_US
dc.subjectGlucocorticoidsen_US
dc.subjectGlucoseen_US
dc.subjectHypercortisolismen_US
dc.subjectManagementen_US
dc.subjectResistanceen_US
dc.subjectAdipocyteen_US
dc.subjectUpdateen_US
dc.titleSerum Adiponectin Level as a Predictor of Subclinical Cushing's Syndrome in Patients with Adrenal Incidentalomaen_US
dc.typeArticleen_US

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