Influence of patient training on persistence, compliance, and tolerability of different dosing frequency regimens of bisphosphonate therapy: An observational study in Turkish patients with postmenopausal osteoporosis
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Association of Orthopaedics and Traumatology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: In our study, we aimed to evaluate the influence of training on compliance and persistence with bisphosphonate treatment given on a weekly vs. monthly basis in postmenopausal osteoporosis patients. Methods: A total of 979 patients with postmenopausal osteoporosis (mean age: 63.2 ± 7.2 years) were included in this national, multicenter, prospective non-interventional observational cohort registry study. Patients were randomized into training (n = 492, 50.3%, mean age: 63.4 ± 7.2 years) and control (n = 487, 49.7%, mean age: 63.0 ± 7.1 years) groups. Patients in each intervention group were given weekly (44.9% and 44.6% for training and control subjects, respectively) or monthly (55.1% and 55.4%, respectively) bisphosphonate regimens. After the initial visit, patients were followed up at three-month intervals throughout 12 months of treatment for evaluation of persistence, compliance and adverse events. Results: On average, 79.4% of the patients were persistent with the treatment with a mean of 350.4 days of duration during the 12-month follow-up period. The mean compliance in the compliant and fully compliant group remained at an average of 86.6%. No significant difference was detected between the training and control groups in terms of compliance and persistence. Significantly longer persistence (360.0 ± 89.0 vs. 345.0 ± 108.0 days; p = 0.035), higher percentage of persistent patients (83.4% vs. 74.2%; p = 0.012) and higher compliance rates (88.8% vs. 83.3%; p = 0.002) were noted in monthly regimen patients in comparison to those given weekly regimen. © 2016 Turkish Association of Orthopaedics and Traumatology.
Açıklama
Anahtar Kelimeler
Bisphosphonate; Compliance; Dosing Regimen; Osteoporosis; Persistence; Training, Bisphosphonic Acid Derivative; Bone Density Conservation Agent; Aged; Clinical Trial; Controlled Study; Drug Administration; Female; Human; Medication Compliance; Middle Aged; Multicenter Study; Osteoporosis, Postmenopausal; Patient Education; Procedures; Prospective Study; Randomized Controlled Trial; Statistics And Numerical Data; Turkey; Aged; Bone Density Conservation Agents; Diphosphonates; Drug Administration Schedule; Female; Humans; Medication Adherence; Middle Aged; Osteoporosis, Postmenopausal; Patient Education As Topic; Prospective Studies; Turkey
Kaynak
Acta Orthopaedica et Traumatologica Turcica
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
50
Sayı
4
