Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats

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dc.authoridGedikbasi, Asuman/0000-0001-7121-6077;
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidGedikbasi, Asuman/AAE-3613-2020
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorAlpsoy, Seref
dc.contributor.authorAktas, Cevat
dc.contributor.authorUygur, Ramazan
dc.contributor.authorTopcu, Birol
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorKarakaya, Osman
dc.date.accessioned2024-06-12T10:59:48Z
dc.date.available2024-06-12T10:59:48Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the antioxidant and anti-apoptotic effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced cardiotoxicity. The rats in the ACE-pretreated group were given a daily dose of 1 ml ACE for 14 days. To induce cardiotoxicity, DOX (30 mg kg-1 body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. To date, no such studies have been performed on the cardioprotective and anti-apoptotic potential of ACE on DOX-induced cardiotoxicity. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in cardiomyocytes of the DOX-treated group with ACE therapy. The DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels, and increased activities of superoxide dismutase, glutathione and glutathione peroxidase in comparison with the DOX-treated group. Creatine kinase, creatine kinase MB, lactate dehydrogenase activities and cardiac troponin I levels were significantly decreased in the DOX + ACE group in comparison with the DOX group. These biochemical and histological disturbances were effectively attenuated on pretreatment with ACE. The present study showed that ACE may be a suitable cardioprotector against toxic effects of DOX. Copyright (C) 2011 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/jat.1738
dc.identifier.endpage208en_US
dc.identifier.issn0260-437X
dc.identifier.issn1099-1263
dc.identifier.issue3en_US
dc.identifier.pmid21996788en_US
dc.identifier.scopus2-s2.0-84873059182en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage202en_US
dc.identifier.urihttps://doi.org/10.1002/jat.1738
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20584
dc.identifier.volume33en_US
dc.identifier.wosWOS:000314070200006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectAllium Cepaen_US
dc.subjectCardiotoxicityen_US
dc.subjectTUNELen_US
dc.subjectAntioxidantsen_US
dc.subjectRaten_US
dc.subjectCytochrome-C Releaseen_US
dc.subjectAdriamycinen_US
dc.subjectProtectionen_US
dc.subjectHearten_US
dc.subjectInhibitionen_US
dc.subjectEfficiencyen_US
dc.subjectDamageen_US
dc.titleAntioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in ratsen_US
dc.typeArticleen_US

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