Determination of sildenafil and tadalafil adulteration by LC-MS/MS and 23 elements by ICP-MS in food supplements

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dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authoridCelik, Saffet/0000-0002-4225-2471
dc.authoriddaşman, mustafa/0000-0003-0556-8845
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.authorwosidCelik, Saffet/R-9630-2017
dc.authorwosiddaşman, mustafa/HPC-3356-2023
dc.contributor.authorOltulu, Cagatay
dc.contributor.authorCelik, Saffet
dc.contributor.authorDasman, Mustafa
dc.date.accessioned2024-06-12T10:50:51Z
dc.date.available2024-06-12T10:50:51Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Aims: Since the increasing prevalence of erectile dysfunction disease, the use of phosphodiesterase type 5 (PDE-5) inhibitors is widespread in the current era. The first and the most known molecule of PDE-5 inhibitors is sildenafil. It is widely used in the market. The second and more developed one is tadalafil. It is known that these substances are found in sexual stimulant food supplements as adulteration. In addition, food supplements can contain metals that can cause haz-ardous activity by accumulating. In our study, 11 randomly chosen sexual stimulant known products are studied which were bought from different stores in Edirne. Methods: Adulteration with sildenafil and tadalafil was determined by LC-MS/MS because of the enhanced accuracy and precision, general applicability, and higher selectivity. Also, the determination of 23 metals, including known heavy metals, was made with ICP-MS. Results: In the study, 7 of 11 samples detected at least 1 compound of sildenafil (up to 92.44 mg in one serving) or tadalafil (up to 23.62 mg in one serving). Neither of the samples exceeded the limits of metal daily intakes that are shown in Table 4.Conclusion: In past studies, adulteration was determined in food supplements, and it is still detected today. The results we obtained are engrossing for the regulations of sexual stimulant food supplement sales. Their additional effects on total daily intake raise health concerns. The data obtained from this study will contribute to inform consumers and health professionals about the status of food supplements in the market.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2023.1206425
dc.identifier.endpage228en_US
dc.identifier.issn2587-2087
dc.identifier.issue2en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2023.1206425
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18154
dc.identifier.volume53en_US
dc.identifier.wosWOS:001110261800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal Of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdulterationen_US
dc.subjectDietary Food Supplementsen_US
dc.subjectMetalsen_US
dc.subjectPDE-5 Inhibitorsen_US
dc.subjectSildenafilen_US
dc.subjectTadalafilen_US
dc.subjectAcute Myocardial-Infarctionen_US
dc.subjectHerbal Dietary-Supplementsen_US
dc.subjectHeavy-Metalsen_US
dc.subjectCitrateen_US
dc.subjectVardenafilen_US
dc.subjectProductsen_US
dc.subjectAnalogsen_US
dc.subjectDrugsen_US
dc.subjectFormulationsen_US
dc.subjectMechanismsen_US
dc.titleDetermination of sildenafil and tadalafil adulteration by LC-MS/MS and 23 elements by ICP-MS in food supplementsen_US
dc.typeArticleen_US

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