Is the prognostic nutritional index a prognostic and predictive factor in metastatic non-small cell lung cancer patients treated with first-line chemotherapy?

Basit Öğe Kaydı
dc.authoridSAKIN, Abdullah/0000-0003-2538-8569
dc.authoridbozkaya, yakup/0000-0002-0180-8349
dc.authorwosidbozkaya, yakup/V-6184-2017
dc.contributor.authorBozkaya, Yakup
dc.contributor.authorKostek, Osman
dc.contributor.authorSakin, Abdullah
dc.contributor.authorOzyukseler, Deniz Tataroglu
dc.contributor.authorSakalar, Teoman
dc.contributor.authorCil, Ibrahim
dc.date.accessioned2024-06-12T11:09:36Z
dc.date.available2024-06-12T11:09:36Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose We aimed to assess the prognostic and predictive significance of pretreatment Onodera's prognostic nutritional index (OPNI) in metastatic non-small cell lung cancer patients (NSCLC) treated with first-line chemotherapy. Materials and methods Patients with metastatic NSCLC who attended five different medical oncology clinics between December 2008 and January 2018 were retrospectively analyzed. The optimal cut-off point for OPNI was performed by a receiver operating characteristic (ROC) curve analysis. Patients were assigned to either the low OPNI group or high OPNI group. Results A total of 333 patients were included in the study. Significant differences between the low and high OPNI groups were found regarding the rates of response to chemotherapy, sex, and hemoglobin level (p < 0.05). The patients in high OPNI group had a longer overall survival (OS) (15.3 vs. 10.6 months, p < 0.001) and progression-free survival (PFS) (6.7 vs. 5.3 months, p < 0.001) compared to the patients in low OPNI group. A multivariate analysis using Cox regression model revealed that a high OPNI score was an independent prognostic factor of OS (HR = 1.535, p = 0.002) and PFS (HR = 1.336, p = 0.014), but failed to demonstrate a statistical significance of pretreatment OPNI scores in predicting treatment response (p = 0.56). Conclusions Pretreatment OPNI is an independent prognostic factor for OS and PFS in metastatic NSCLC patients treated with first-line chemotherapy. Thus, it may be used as easily calculated and low-cost prognostic tool in the routine clinical practice in this patient group.en_US
dc.identifier.doi10.1007/s00520-019-05055-x
dc.identifier.endpage2282en_US
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue5en_US
dc.identifier.pmid31471631en_US
dc.identifier.scopus2-s2.0-85071451916en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2273en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-019-05055-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22877
dc.identifier.volume28en_US
dc.identifier.wosWOS:000520833300029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOnodera's Prognostic Nutritional Indexen_US
dc.subjectFirst-Line Chemotherapyen_US
dc.subjectMetastasticen_US
dc.subjectNon-Small Cell Lung Canceren_US
dc.subjectPrognosticen_US
dc.subjectSystemic Inflammatory Responseen_US
dc.subjectColorectal-Canceren_US
dc.subjectSurvivalen_US
dc.subjectImpacten_US
dc.subjectOutcomesen_US
dc.titleIs the prognostic nutritional index a prognostic and predictive factor in metastatic non-small cell lung cancer patients treated with first-line chemotherapy?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu