In Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) of Aprepitant for Enhanced Solubility

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dc.authoridNazli, Hakan/0000-0001-5763-1450
dc.authoridOZSOY, YILDIZ/0000-0002-9110-3704
dc.authorwosidNazli, Hakan/ABI-5317-2020
dc.contributor.authorNazli, Hakan
dc.contributor.authorMesut, Burcu
dc.contributor.authorOzsoy, Yildiz
dc.date.accessioned2024-06-12T10:52:27Z
dc.date.available2024-06-12T10:52:27Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAprepitant (APR) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its low aqueous solubility. The objective of the current work is to develop self-nanoemulsifying drug delivery systems (SNEDDS) of APR to enhance its aqueous solubility. Preformulation studies involving screening of excipients for solubility and emulsification efficiency were carried out. Pseudo ternary phase diagrams were constructed with blends of oil (Imwitor(R) 988), cosolvent (Transcutol(R) P), and various surfactants (Kolliphor(R) RH40, Kolliphor(R) ELP, Kolliphor(R) HS15). The prepared SNEDDS were characterized for droplet size and nanoemulsion stability after dilution. Supersaturated SNEDDS (super-SNEDDS) were prepared to increase the quantity of loaded APR into the formulations. HPMC, PVP, PVP/VA, and Soluplus(R) were used as polymeric precipitation inhibitors (PPI). PPIs were added to the formulations at 5% and 10% by weight. The influence of the PPIs on drug precipitation was investigated. In vitro lipolysis test was carried out to simulate digestion of formulations in the gastrointestinal tract. Optimized super-SNEDDS were formulated into free-flowing granules by adsorption on the porous carriers such as Neusilin(R) US2. In vitro dissolution studies of solid super-SNEDDS formulation revealed an increased dissolution rate of the drug due to enhanced solubility. Consequently, a formulation to improve the solubility and potentially bioavailability of the drug was developed.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects Unit [TSA-2017-23829]en_US
dc.description.sponsorshipFunding This research was funded by Istanbul University Scientific Research Projects Unit, Grant Number TSA-2017-23829.en_US
dc.identifier.doi10.3390/ph14111089
dc.identifier.issn1424-8247
dc.identifier.issue11en_US
dc.identifier.pmid34832871en_US
dc.identifier.scopus2-s2.0-85118402641en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ph14111089
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18703
dc.identifier.volume14en_US
dc.identifier.wosWOS:000724775600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofPharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAprepitanten_US
dc.subjectSupersaturated SNEDDSen_US
dc.subjectSolid SNEDDSen_US
dc.subjectSolubility Enhancementen_US
dc.subjectSoluplus(R)en_US
dc.subjectImwitor(R) 988en_US
dc.subjectOral Bioavailability Enhancementen_US
dc.subjectVivo Performanceen_US
dc.subjectFormulationen_US
dc.subjectDesignen_US
dc.subjectChemotherapyen_US
dc.subjectMechanismsen_US
dc.subjectPreventionen_US
dc.titleIn Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) of Aprepitant for Enhanced Solubilityen_US
dc.typeArticleen_US

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