A set of clinical and laboratory markers differentiates hyper-IgE syndrome from severe atopic dermatitis

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dc.authoridKiykim, Ayca/0000-0001-5821-3963
dc.authoridOZEN, AHMET/0000-0002-9065-1901
dc.authoridCelik, Velat/0000-0002-8893-9420
dc.authoridOGULUR, ISMAIL/0000-0001-8282-7762
dc.authoridKolukisa, Burcu/0000-0002-2399-8630
dc.authorwosidKiykim, Ayca/J-6400-2017
dc.authorwosidOgulur, Ismail/GYV-4415-2022
dc.authorwosidOZEN, AHMET/R-6749-2017
dc.authorwosidAydiner, Elif/HKN-1599-2023
dc.authorwosidCeliksoy, Mehmet Halil/A-3889-2015
dc.authorwosidBilgic eltan, Sevgi/ABF-6314-2020
dc.authorwosidCelik, Velat/IUN-0044-2023
dc.contributor.authorKasap, Nurhan
dc.contributor.authorCelik, Velat
dc.contributor.authorIsik, Sakine
dc.contributor.authorCennetoglu, Pakize
dc.contributor.authorKiykim, Ayca
dc.contributor.authorEltan, Sevgi Bilgic
dc.contributor.authorNain, Ercan
dc.date.accessioned2024-06-12T11:03:34Z
dc.date.available2024-06-12T11:03:34Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHyper-IgE syndrome (HIES) patients may share many features observed in severe atopic dermatitis (SAD), making a diagnostic dilemma for physicians. Determining clinical and laboratory markers that distinguish both disorders could provide early diagnosis and treatment. We analyzed patients (DOCK8 deficiency:14, STAT3-HIES:10, SAD:10) with early-onset SAD. Recurrent upper respiratory tract infection and pneumonia were significantly frequent in HIES than SAD patients. Characteristic facial appearance, retained primary teeth, skin abscess, newborn rash, and pneumatocele were more predictable for STAT3-HIES, while mucocutaneous candidiasis and Herpes infection were common in DOCK8 deficiency, which were unusual in SAD group. DOCK8-deficient patients had lower CD3(+) and CD4(+)T cells with a senescent phenotype that unique for this form of HIES. Both DOCK8 deficiency and STAT3-HIES patients exhibited reduced switched memory B cells compared to the SAD patients. These clinical and laboratory markers are helpful to differentiate HIES from SAD patients.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [318S202]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (318S202).en_US
dc.identifier.doi10.1016/j.clim.2020.108645
dc.identifier.issn1521-6616
dc.identifier.issn1521-7035
dc.identifier.pmid33301882en_US
dc.identifier.scopus2-s2.0-85097777826en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.clim.2020.108645
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21692
dc.identifier.volume223en_US
dc.identifier.wosWOS:000613283300013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofClinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyper-Ige Syndromeen_US
dc.subjectDOCK8 Deficiencyen_US
dc.subjectSTAT3 Deficiencyen_US
dc.subjectSevere Atopic Dermatitisen_US
dc.subjectDock8 Deficiencyen_US
dc.subjectStat3 Mutationsen_US
dc.subjectCombined Immunodeficiencyen_US
dc.subjectSignal Transduceren_US
dc.subjectGuidelinesen_US
dc.subjectPhenotypeen_US
dc.subjectDedicatoren_US
dc.subjectActivatoren_US
dc.subjectFeaturesen_US
dc.subjectDiseaseen_US
dc.titleA set of clinical and laboratory markers differentiates hyper-IgE syndrome from severe atopic dermatitisen_US
dc.typeArticleen_US

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