Protective effects of vitamin C, alone or in combination with vitamin A, on endotoxin-induced oxidative renal tissue damage in rats

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dc.authoridUz, Yesim/0000-0002-0381-4590
dc.contributor.authorKanter, M
dc.contributor.authorCoskun, O
dc.contributor.authorArmutcu, F
dc.contributor.authorUz, YH
dc.contributor.authorKizilay, G
dc.date.accessioned2024-06-12T11:00:25Z
dc.date.available2024-06-12T11:00:25Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study was designed to investigate the protective effects of vitamin C and vitamin A on oxidative renal tissue damage. Male Wistar rats were given an intraperitoneal injection of 0.5 ml saline (control) or 0.5 ml solution of lipopolysaccharide (10 mg/kg), which caused endotoxemia. Immediately (within 5 min) after the endotoxin injection, the endotoxemic rats were untreated or treated with intraperitoneal injection of vitamin A (195 mg/kg bw), vitamin C (500 mg/kg bw) or their combination. After 24 hours, tissue and blood samples were obtained for histopathological and biochemical investigation. Endotoxin injection caused renal tissue damage and increased erythrocyte and tissue malondialdehyde (MDA) and serum nitric oxide (NO), urea and creatinine concentrations, but decreased the superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities compared to the parameters of control animals. Treatment with vitamin C or with vitamins C and A significantly decreased the MDA levels and serum NO, urea and creatinine levels, recovered the antioxidant enzyme activities (SOD, GSH-Px and CAT), and prevented the renal tissue damage in endotoxemic rats. In contrast, vitamin A alone did not change the altered parameters except for creatinine levels. Notably, the better effects were observed when vitamins A and C given together. It is concluded that vitamin C treatment, alone or its combination with vitamin A, may be beneficial in preventing endotoxin-induced oxidative renal tissue damage and shows potential for clinical use. - endotoxemia; vitamin A; vitamin C; malondialdehyde; kidney (c) 2005 Tohoku University Medical Press.en_US
dc.identifier.doi10.1620/tjem.206.155
dc.identifier.endpage162en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue2en_US
dc.identifier.pmid15888972en_US
dc.identifier.scopus2-s2.0-21244442677en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.206.155
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20820
dc.identifier.volume206en_US
dc.identifier.wosWOS:000228824400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal Of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndotoxemiaen_US
dc.subjectVitamin Aen_US
dc.subjectVitamin Cen_US
dc.subjectMalondialdehydeen_US
dc.subjectKidneyen_US
dc.subjectAntioxidantsen_US
dc.subjectSupplementationen_US
dc.subjectZincen_US
dc.titleProtective effects of vitamin C, alone or in combination with vitamin A, on endotoxin-induced oxidative renal tissue damage in ratsen_US
dc.typeArticleen_US

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