Levels of serum platelet-derived growth factor-? (PDGF-?) and factors affecting mortality in patients with acute myocardial infarction

Basit Öğe Kaydı
dc.contributor.authorÖzbilen, Mehmet Selim
dc.contributor.authorSayhan, Mustafa Burak
dc.contributor.authorSalt, Ömer
dc.contributor.authorDıbırdık, Ilker
dc.date.accessioned2024-06-12T10:05:38Z
dc.date.available2024-06-12T10:05:38Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAcute myocardial infarction (AMI) is the necrosis in the heart tissue resulting from obstruction of the coronary arteries. The main phenomenon in coronary artery disease and the formation of acute coronary syndromes is atherosclerosis which develops following the formation of coronary plaque. Platelet-derived growth factors (PDGF) that are produced by platelets, macrophages and endothelial cells are actively involved in atherosclerosis. The present study is, therefore, intended to investigate the diagnostic value of PDGF-?, as well as the factors affecting mortality in patients with acute myocardial infarction. According to the comparison of the study groups in terms of their PDGF-? levels, the NSTEMI group was found to have the highest level of PDGF-?. In the intergroup comparison of the subgroups of the patient group, the NSTEMI group was found to have significantly higher levels of PDGF-? than the STEMI group had (Post-Hoc test p=0.001). In the analyses of the values measured in the blood samples collected at the time of admission to the ED, PDGF-? was found to have a moderate positive linear relationship with WBC, troponin and lactate values. According to the analyses of the subgroups of the patient group, only in the NSTEMI group was there a moderate positive linear relationship between troponin and PDGF-?. We investigated whether serum PDGF-? is the new prognostic biomarker for AMI, serum PDGF-? levels were significantly higher, especially in patients with NSTEMI. However, in order for serum PDGF-? levels to be used as a marker for predicting prognosis, further comprehensive studies that focus on this subject are needed.en_US
dc.identifier.doi10.5455/medscience.2022.02.047
dc.identifier.endpage1014en_US
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage1098en_US
dc.identifier.trdizinid1131037en_US]
dc.identifier.urihttps://doi.org/10.5455/medscience.2022.02.047
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1131037
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13553
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLevels of serum platelet-derived growth factor-? (PDGF-?) and factors affecting mortality in patients with acute myocardial infarctionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu