Intravenous paracetamol reduced the use of opioids, extubation time, and opioid-related adverse effects after major surgery in intensive care unit

Basit Öğe Kaydı
dc.authoridkavalcı, gulsum/0000-0002-8245-4721;
dc.authorwosidkavalcı, gulsum/GVU-5232-2022
dc.authorwosidtecik, ahmet/GPX-3080-2022
dc.contributor.authorMemis, Dilek
dc.contributor.authorInal, Mehmet Turan
dc.contributor.authorKavalci, Gulsum
dc.contributor.authorSezer, Atakan
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:12:03Z
dc.date.available2024-06-12T11:12:03Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study assessed the analgesic efficacy, side effects, and time to extubation of intravenous paracetamol when administered as an adjuvant to intravenous meperidine after major surgery in intensive care unit (ICU). Material: Patients were randomized postoperatively into 2 groups in ICU. Patients received either 100 mL of serum saline intravenous (IV) every 6 hours and IV meperidine (n = 20 group M) or IV paracetamol 1 g every 6 hours and IV meperidine (n = 20, group MP) into a peripheral vein for 24 hours. Behavioral Pain Scale (BPS) is used until extubation, and visual analog score (VAS) is used after extubation. When BPS and VAS values were more than 4, meperidine, I mg/kg IV, was administered and noted in 2 groups. Pain scores, total meperidine consumption, time to extubation, sedation scores, and side effects are 24-hour postoperatively noted. Results: Behavioral Pain Scale and VAS scores are significantly lower in group paracetamol-meperidine at 24 hours (P<.05). In group MP, postoperative meperidine consumption (76.75 +/- 18.2 mg vs. 198 +/- 66.4 mg) and extubation time (64.3 +/- 40.6 min vs. 204.5 +/- 112.7 min) were lower than in group M (P<.01). In addition to, postoperative nausea-vomiting and sedation scores were significantly lower in group MP when compared with group M (P<.05). Conclusion: We have demonstrated important clinical benefits by the addition of 4 g/d of paracetamol to meperidine after major surgery. This benefit has been shown in a range of patients under routine clinical conditions and therefore has important practical consequences in ICU. These data suggest that intravenous paracetamol is a useful component of the multimodal analgesia model, especially after major surgery. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jcrc.2009.12.012
dc.identifier.endpage462en_US
dc.identifier.issn0883-9441
dc.identifier.issn1557-8615
dc.identifier.issue3en_US
dc.identifier.pmid20189753en_US
dc.identifier.scopus2-s2.0-78149492554en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage458en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2009.12.012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23020
dc.identifier.volume25en_US
dc.identifier.wosWOS:000282149100013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParacetamol Intravenousen_US
dc.subjectMeperidineen_US
dc.subjectMajor Surgeryen_US
dc.subjectPostoperative Analgesiaen_US
dc.subjectExtubation Timeen_US
dc.subjectIntensive Care Uniten_US
dc.subjectBehavioral Pain Scaleen_US
dc.subjectPostoperative Painen_US
dc.subjectBalanced Analgesiaen_US
dc.subjectCritically-Illen_US
dc.subjectPropacetamolen_US
dc.subjectAcetaminophenen_US
dc.subjectManagementen_US
dc.subjectConsumptionen_US
dc.subjectRationaleen_US
dc.subjectEfficacyen_US
dc.titleIntravenous paracetamol reduced the use of opioids, extubation time, and opioid-related adverse effects after major surgery in intensive care uniten_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu