Pruritus: Do A? fibers play a role?

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dc.contributor.authorTekatas, Aslan
dc.contributor.authorArican, Ozer
dc.contributor.authorGuler, Sibel
dc.contributor.authorAynaci, Ozer
dc.contributor.authorDincer, Nejla
dc.date.accessioned2024-06-12T10:50:13Z
dc.date.available2024-06-12T10:50:13Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNeuropathological and molecular basis of pruritus has not been clarified and the presence of certain specific neural circuits have been proposed. Our aim in this study was to evaluate the role of A fibers in the neural circuits of pruritus by cutaneous silent period (CSP). Thirty-six patients with chronic idiopathic generalized pruritus and 32 healthy controls were enrolled in the study. CSP and nerve conduction studies of upper and lower extremities were performed in both groups. Latencies of CSP in the upper and lower extremities were observed to be prolonged in the patient group compared with the controls while durations were shortened (all P<0.001). However, these values were not correlated with sex, age, duration or severity of the disease (all P>0.05). Our data suggest that pruritus may be developed by a nerve conduction abnormality in the afferent fibers of A, or cortical hypersensitivity, abnormality of the cortical inhibitory mechanisms or lack of inhibition in the intermediate spinal inhibitory neurons generating CSP. This topic needs to be evaluated thoroughly in larger series with more detailed studies.en_US
dc.identifier.doi10.1111/1346-8138.12340
dc.identifier.endpage101en_US
dc.identifier.issn0385-2407
dc.identifier.issn1346-8138
dc.identifier.issue1en_US
dc.identifier.pmid24354758en_US
dc.identifier.scopus2-s2.0-84892815698en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.1111/1346-8138.12340
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17917
dc.identifier.volume41en_US
dc.identifier.wosWOS:000329797100018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA Fibersen_US
dc.subjectCutaneous Silent Perioden_US
dc.subjectNerve Conductions Studyen_US
dc.subjectNeural Circuitsen_US
dc.subjectPruritusen_US
dc.subjectCutaneous-Silent-Perioden_US
dc.subjectCentral Sensitizationen_US
dc.subjectItchen_US
dc.subjectNeuronsen_US
dc.subjectPainen_US
dc.subjectPathogenesisen_US
dc.subjectStimulationen_US
dc.subjectNociceptorsen_US
dc.subjectAfferentsen_US
dc.titlePruritus: Do A? fibers play a role?en_US
dc.typeArticleen_US

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