Protective effect of curcumin on cyclosporin A-induced endothelial dysfunction, antioxidant capacity, and oxidative damage

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dc.contributor.authorSagiroglu, Tamer
dc.contributor.authorKanter, Mehmet
dc.contributor.authorYagci, Mehmet Ali
dc.contributor.authorSezer, Atakan
dc.contributor.authorErboga, Mustafa
dc.date.accessioned2024-06-12T10:59:06Z
dc.date.available2024-06-12T10:59:06Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCyclosporin A (CsA) is the most widely used immunosuppressive drug for preventing graft rejection and autoimmune disease. However, the therapeutic treatment induces several side effects such as nephrotoxicity, cardiotoxicity, hypertension, and hepatotoxicity. Curcumin has been successfully used as a potent antioxidant against many pathophysiological states. This experimental study was performed to test, during CsA treatment, the alterations of curcumin antioxidant properties against CsA-induced endothelial dysfunction. Rats were divided into four groups: control, curcumin alone, CsA, and CsA + curcumin; each group containing eight animals. The animals in the CsA + curcumin group were treated with CsA (10 days, 25 mg/kg, orally) and curcumin (15 days, 200 mg/kg, orally, starting 5 days before CsA administration). At the end of the treatments, the animals were killed; serum and aorta tissue were treated for biochemical and morphological analyses. The results indicate that CsA-induced aortic endothelial dysfunction was characterized by morphological and ultrastructural alterations in tissue architecture, changes in malondialdehyde and ferric reducing/antioxidant power levels, and increase in endothelial nitric oxide synthase and terminal-deoxynucleotidyl-transferase mediated dUTP nick end labeling (TUNEL) expression. In conclusion, our data suggest that the imbalance between production of free oxygen radicals and antioxidant defence systems, due to CsA administration, is a mechanism responsible for oxidative stress. Moreover, we show that curcumin plays a protective action against CsA-induced endothelial dysfunction and oxidative stress, as supported by biochemical, ultrastructural, immunohistochemical, and TUNEL results.en_US
dc.identifier.doi10.1177/0748233712456065
dc.identifier.endpage327en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue4en_US
dc.identifier.pmid22903178en_US
dc.identifier.scopus2-s2.0-84899836131en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage316en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712456065
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20306
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335087800004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclosporin Aen_US
dc.subjectOxidative Stresen_US
dc.subjectEnos And TUNELen_US
dc.subjectElectron Microscopyen_US
dc.subjectAntioxidant Capacityen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectCurcuminen_US
dc.subjectImmunosuppressive Drugsen_US
dc.subjectCardiovascular Eventsen_US
dc.subjectRaten_US
dc.subjectHypertensionen_US
dc.subjectNephrotoxicityen_US
dc.subjectStressen_US
dc.subjectCalcineurinen_US
dc.subjectMechanismsen_US
dc.subjectApoptosisen_US
dc.subjectMelatoninen_US
dc.titleProtective effect of curcumin on cyclosporin A-induced endothelial dysfunction, antioxidant capacity, and oxidative damageen_US
dc.typeArticleen_US

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