MEAN PLATELET VOLUME LEVELS IN PATIENTS WITH OVERT HYPOTHYROIDISM BEFORE AND AFTER LEVOTHYROXINE TREATMENT

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dc.authoridbilir, bulent/0000-0003-2112-4056
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.contributor.authorAtile, N. Soysal
dc.contributor.authorBilir, B. Ekiz
dc.contributor.authorBilir, B.
dc.contributor.authorGuldiken, S.
dc.date.accessioned2024-06-12T11:08:09Z
dc.date.available2024-06-12T11:08:09Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. Hypothyroidism accelerates atherosclerosis and thyroid hormone replacement inhibits this progression. Platelet activation and aggregation play major role in the pathophysiology of atherothrombosis. Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherosclerosis. The present study was designed to evaluate levels of MPV before and after the levothyroxine (LT4) treatment in patients with overt hypothyroidism. Design. The study included 30 Hashimoto's thyroiditis patients with overt hypothyroidism and 20 healthy control subjects. Hypothyroid patients were given LT4 replacement therapy. Fasting glucose, lipid levels and blood counts were assessed before and after the maintenance of euthyroidism. Results. Fasting glucose, platelet count and all lipid parameters were similar between the two groups. The mean MPV level of hypothyroid patients was hither than of the control group (p<0.01). A significant decrease in the mean MPV level was detected after the maintenance of euthyroidism with LT4 treatment (p<0.05). Conclusion. This study suggests that patients with overt hypothyroidism tend to have increased platelet activation. This activation may cause increased risk of atherothrombotic complications that may be reversed by treatment of hypothyroidism.en_US
dc.identifier.doi10.4183/aeb.2012.607
dc.identifier.endpage613en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84872328004en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage607en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2012.607
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22322
dc.identifier.volume8en_US
dc.identifier.wosWOS:000312679100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectHypothyroidismen_US
dc.subjectLevothyroxine Treatmenten_US
dc.subjectActivatable Fibrinolysis Inhibitoren_US
dc.subjectSmall-Sized Plateletsen_US
dc.subjectSubclinical Hypothyroidismen_US
dc.subjectBlood-Coagulationen_US
dc.subjectRisk-Factoren_US
dc.subjectModerateen_US
dc.subjectTherapyen_US
dc.subjectAntigenen_US
dc.subjectDiseaseen_US
dc.titleMEAN PLATELET VOLUME LEVELS IN PATIENTS WITH OVERT HYPOTHYROIDISM BEFORE AND AFTER LEVOTHYROXINE TREATMENTen_US
dc.typeArticleen_US

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