The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage

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dc.authoridUYSAL, HAMDI/0000-0002-2289-1815
dc.authorwosidUYSAL, HAMDI/AAF-9708-2020
dc.contributor.authorKanter, M
dc.contributor.authorCoskun, O
dc.contributor.authorUysal, H
dc.date.accessioned2024-06-12T11:09:13Z
dc.date.available2024-06-12T11:09:13Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to assess the possible protective effects of Nigella sativa (NS) and its constituent, thymoquinone (TQ) on ethanol-induced gastric mucosal damage in an experimental model. Forty male rats aged four months were divided into four groups (each group containing ten animals); the control group received physiologic saline (10 ml kg(-1)) and the ethanol group had taken 1 ml (per rat) absolute alcohol by gavage. The third and fourth groups also received NS (500 mg kg(-1)) and TQ (10 mg kg(-1)) by gavage 1 h before alcohol administration, respectively. Both drugs (NS and TQ) could protect the gastric mucosa against the injurious effect of absolute alcohol and promote ulcer healing as evidenced from the ulcer index values. Gastric damage was confirmed histomorphometrically by significant increases in the number of mast cells (MC) and gastric erosions in ethanol treated rats. The NS treatment significantly decreased the number of MC and reduced the area of gastric erosions. Likewise, TQ treatment was also able to reduce the number of MC and the gravity of gastric mucosal lesions, but to lesser extent compared to NS. Gastric tissue histamine levels and myeloperoxidase activities were found to be increased in ethanol treated rats, and NS or TQ treatment reversed these increases. Results obtained from this study suggest that both drugs, particularly NS could partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects could be due to their antiperoxidative, antioxidant and antihistaminic effects.en_US
dc.identifier.doi10.1007/s00204-005-0037-1
dc.identifier.endpage224en_US
dc.identifier.issn0340-5761
dc.identifier.issn1432-0738
dc.identifier.issue4en_US
dc.identifier.pmid16240107en_US
dc.identifier.scopus2-s2.0-33645403640en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1007/s00204-005-0037-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22727
dc.identifier.volume80en_US
dc.identifier.wosWOS:000236425400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella Sativaen_US
dc.subjectThymoquinoneen_US
dc.subjectUlceren_US
dc.subjectAntioxidanten_US
dc.subjectAntihistaminicen_US
dc.subjectRaten_US
dc.subjectOxidative Stressen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectFree-Radicalsen_US
dc.subjectVolatile Oilen_US
dc.subjectRat Stomachen_US
dc.subjectMechanismen_US
dc.subjectInjuryen_US
dc.subjectElucidationen_US
dc.subjectInhibitionen_US
dc.subjectHistamineen_US
dc.titleThe antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damageen_US
dc.typeArticleen_US

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