Vasodilation Responses to Non-Selective ?-Adrenergic Blockage of Coronary Bypass Grafts in Diabetic and Non-Diabetic Patients: In Vitro Study

Basit Öğe Kaydı
dc.authoridgocmez, semil selcen/0000-0001-7341-4907;
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.contributor.authorGurkan, Selami
dc.contributor.authorGur, Ozcan
dc.contributor.authorGur, Demet Ozkaramanli
dc.contributor.authorGocmez, Semil Selcen
dc.contributor.authorEge, Turan
dc.date.accessioned2024-06-12T11:12:20Z
dc.date.available2024-06-12T11:12:20Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Adrenergic tonus is increased in atherosclerotic coronary arteries. In this study, we aimed to demonstrate in vitro effects of phentolamine, a reversible nonselective alpha (a) adrenergic blocker, on coronary artery bypass grafts (CABG) and compare its effects in diabetic and nondiabetic patients. Methods: A total number of 30 patients (15 diabetic and 15 nondiabetic) who were assigned to elective CABG surgery were enrolled into the study. For both groups of patients, 16 internal mammarian artery (IMA) samples, 16 saphenous vein (SV) samples and 16 radial artery (RA) samples were collected and studied in the tissue bath system. The vasodilatation responses to increasing doses of phentolamine were recorded. Results: When grafts were compared in terms of amount of vasodilatation to phentolamine, IMA had the most prominent vasodilatation followed by RA and SV respectively. Although the vasodilatation responses in nondiabetic patients were numerically higher than diabetic patients, there was no statistically difference between the groups. Conclusion: Phentolamine, a nonselective a adrenergic blocker, is proven to have equal vasodilatory effects in diabetic and nondiabetic CABG grafts and can safely be used both intravenously and topically in the perioperative period.en_US
dc.identifier.doi10.5761/atcs.oa.14-00176
dc.identifier.endpage150en_US
dc.identifier.issn1341-1098
dc.identifier.issn2186-1005
dc.identifier.issue2en_US
dc.identifier.pmid25273273en_US
dc.identifier.scopus2-s2.0-84928034096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://doi.org/10.5761/atcs.oa.14-00176
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23132
dc.identifier.volume21en_US
dc.identifier.wosWOS:000353145700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedical Tribune Incen_US
dc.relation.ispartofAnnals Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhentolamineen_US
dc.subjectCoronary Artery Bypass Graften_US
dc.subjectVasodilatationen_US
dc.subjectVasoconstrictionen_US
dc.subjectArteryen_US
dc.subjectPhentolamineen_US
dc.subjectConstrictionen_US
dc.titleVasodilation Responses to Non-Selective ?-Adrenergic Blockage of Coronary Bypass Grafts in Diabetic and Non-Diabetic Patients: In Vitro Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu