Antioxidant and Tyrosinase Inhibitory Activities of Flavonoids from Trifolium nigrescens Subsp petrisavi

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dc.authoridÖztürk, Mehmet/0000-0001-8932-4535
dc.authoridTopcu, Gulacti/0000-0002-7946-6545
dc.authoridTopcu, Gulacti/0000-0002-7946-6545
dc.authoridSABUDAK, Temine/0000-0003-4384-4265
dc.authorwosidÖztürk, Mehmet/JFJ-3399-2023
dc.authorwosidÖztürk, Mehmet/W-4649-2017
dc.authorwosidTopcu, Gulacti/AAH-8305-2019
dc.authorwosidTopcu, Gulacti/C-8344-2015
dc.authorwosidSABUDAK, Temine/AAG-6784-2019
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorSabudak, Temine
dc.contributor.authorOzturk, Mehmet
dc.contributor.authorTopcu, Gulacti
dc.date.accessioned2024-06-12T11:01:45Z
dc.date.available2024-06-12T11:01:45Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTrifolium nigrescens was researched for its chemical constituents for the first time. Bioassay-guided isolation of the EtOAc extract from the leaves of T. nigrescens resulted in the purification of a new biflavone, 4',5,5 '',7,7 ''-pentahydroxy-3',3'-dimethoxy-3-O-beta-D-glucosyl-3 '',4'-O-biflavone (1) along with eleven known compounds consisting of three phenolics (2-4), and eight flavonoid glycosides (5-12). Their structures were determined by extensive ID and 2D NMR, and MS data analyses. The isolated compounds were evaluated for their antioxidant activity and inhibitory activity on mushroom tyrosinase. Highly potent inhibitions Were found by compounds 7 (IC50 = 0.38 mM), 8 (IC50 = 0.19 mM), and 12 (IC50 = 0.26 mM) when compared with standard tyrosinase inhibitors kojic acid (IC50 = 0.67 mM) and L-mimosine (IC50 = 0.64 mM). The antioxidative effect of the isolated compounds and the extracts were determined by using, beta-carotene-linoleic acid, DPPH center dot scavenging, ABTS(+center dot) scavenging, superoxide scavenging, and CUPRAC assays. The experimental findings indicated that all the compounds demonstrated activity in all antioxidant activity tests employed except for the compounds 2-6. Compounds 2-6 showed moderate activity only in ABTS(+center dot) scavenging assay. The new compound 1 exhibited better activity than standard alpha-tocopherol in DPPH center dot scavenging, and ABTS(+center dot) scavenging assays. The results show that T. nigrescens can be regarded as a potential source of antioxidant compounds and tyrosinase inhibitors of significance in both the pharmaceutical and food industries.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [TBAG 108T779]en_US
dc.description.sponsorshipWe thank TUBITAK (The Scientific and Technological Research Council of Turkey) for financial support of the project (TBAG 108T779).en_US
dc.identifier.doi10.1021/jf403669k
dc.identifier.endpage12603en_US
dc.identifier.issn0021-8561
dc.identifier.issn1520-5118
dc.identifier.issue51en_US
dc.identifier.pmid24328319en_US
dc.identifier.scopus2-s2.0-84891439638en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage12598en_US
dc.identifier.urihttps://doi.org/10.1021/jf403669k
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21001
dc.identifier.volume61en_US
dc.identifier.wosWOS:000329137600016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofJournal Of Agricultural And Food Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFabaceaeen_US
dc.subjectT. Nigrescens Subsp Petrisavien_US
dc.subjectFlavonoidsen_US
dc.subjectPhenolic Compoundsen_US
dc.subjectTyrosinase Inhibitory Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectExtractsen_US
dc.titleAntioxidant and Tyrosinase Inhibitory Activities of Flavonoids from Trifolium nigrescens Subsp petrisavien_US
dc.typeArticleen_US

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