Protective effect of everolimus on renal ischemia reperfusion injury in rats

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dc.authoridTorun, Nese/0000-0002-5597-676X
dc.authoridsagiroglu, gonul/0000-0002-1189-4973
dc.authorwosidsagiroglu, gönül/AAB-4472-2021
dc.authorwosidSagiroglu, Gonul/ABH-1345-2021
dc.authorwosidTorun, Nese/AAE-2718-2021
dc.contributor.authorSagiroglu, Tamer
dc.contributor.authorSezer, Atakan
dc.contributor.authorTorun, Nese
dc.contributor.authorYalta, Tulin
dc.contributor.authorYagci, Mehmet Ali
dc.contributor.authorSagiroglu, Gonul
dc.contributor.authorCopuroglu, Elif
dc.date.accessioned2024-06-12T11:22:38Z
dc.date.available2024-06-12T11:22:38Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effect of everolimus and tacrolimus pretreatments on renal morphology and function in a rat ischemia reperfusion (I/R) model. Twenty-eight male Sprague-Dawley rats were randomly assigned to saline sham operation, saline I/R (IR), tacrolimus I/R (TRL I/R) and everolimus I/R (ERL I/R) groups. Saline and active treatments were administered intraperitoneally for seven consecutive days before the surgery. The suprarenal aorta was clamped to achieve warm ischemia, except in the sham group. Right nephrectomy was performed in all animals and histology was examined. Renal function was assessed on post-operative Day 7 by Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy, glomerular filtration rate (GFR) and serum biochemistry. Both everolimus and tacrolimus preserved serum creatinine and blood urea nitrogen levels, but only everolimus preserved GFR (0.74 +/- 0.36, 1.20 +/- 0.37 and 2.24 +/- 0.32 mL/min for I/R, TRL I/R and ERL I/R, respectively, P < 0.001). %ID values for sham, I/R, TRL I/R and ERL I/R were 55 +/- 3, 47 +/- 4, 45 +/- 6 and 62 +/- 7 (P < 0.001). On histologic evaluation, ERL I/R showed less tubular damage and necrosis than I/R, as well as TRL I/R. Within the confines of this rat warm ischemia model, everolimus pre-treatment was useful in preserving renal function following I/R injury. The possibility of using everolimus as a pre-conditioning agent for I/R injury in kidney transplantation should be further explored.en_US
dc.identifier.doi10.4103/1319-2442.128512
dc.identifier.endpage302en_US
dc.identifier.issn1319-2442
dc.identifier.issn2320-3838
dc.identifier.issue2en_US
dc.identifier.pmid24625994en_US
dc.identifier.scopus2-s2.0-84899130083en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://doi.org/10.4103/1319-2442.128512
dc.identifier.urihttps://hdl.handle.net/20.500.14551/26011
dc.identifier.volume25en_US
dc.identifier.wosWOS:000219138900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofSaudi Journal Of Kidney Diseases And Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleProtective effect of everolimus on renal ischemia reperfusion injury in ratsen_US
dc.typeArticleen_US

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