Contribution of genotypes in Prothrombin and Factor V Leiden to COVID-19 and disease severity in patients at high risk for hereditary thrombophilia

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dc.authoridSüer, Kaya/0000-0002-2565-3425
dc.authoridKiraz, Aslıhan/0000-0001-7317-2717
dc.authoridErgoren, Mahmut Cerkez/0000-0001-9593-9325
dc.authoridArslan Ateş, Esra/0000-0001-5552-8134
dc.authoridUnal Evren, Emine/0000-0001-9455-0473
dc.authoridALAVANDA, CEREN/0000-0002-7327-3849
dc.authoridevren, hakan/0000-0001-8247-8144
dc.authorwosidSüer, Kaya/GNM-8453-2022
dc.authorwosidKiraz, Aslıhan/HSF-6928-2023
dc.authorwosidErgoren, Mahmut Cerkez/D-8491-2018
dc.authorwosidArslan Ateş, Esra/AAM-1394-2021
dc.authorwosidUnal Evren, Emine/AAB-4809-2022
dc.authorwosidALAVANDA, CEREN/ABD-1895-2021
dc.authorwosidevren, hakan/AAQ-9755-2020
dc.contributor.authorKiraz, Aslihan
dc.contributor.authorSezer, Ozlem
dc.contributor.authorAlemdar, Adem
dc.contributor.authorCanbek, Sezin
dc.contributor.authorDuman, Nilgun
dc.contributor.authorBisgin, Atil
dc.contributor.authorCora, Tulin
dc.date.accessioned2024-06-12T10:58:42Z
dc.date.available2024-06-12T10:58:42Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThrombotic and microangiopathic effects have been reported in COVID-19 patients. This study examined the contribution of the hereditary thrombophilia factors Prothrombin (FII) and Factor V Leiden (FVL) genotypes to the severity of COVID-19 disease and the development of thrombosis. This study investigated FII and FVL alleles in a cohort of 9508 patients (2606 male and 6902 female) with thrombophilia. It was observed that 930 of these patients had been infected by SARS-CoV-2 causing COVID-19. The demographic characteristics of the patients and their COVID-19 medical history were recorded. Detailed clinical manifestations were analyzed in a group of cases (n = 4092). This subgroup was age and gender-matched. FII and FVL frequency data of healthy populations without thrombophilia risk were obtained from Bursa Uludag University Medical Genetic Department's Exome Databank. The ratio of males (31.08%; 27.01%) and the mean age (36.85 & PLUSMN; 15.20; 33.89 & PLUSMN; 14.14) were higher among COVID-19 patients compared to non-COVID-19 patients. The prevalence of FVL and computerized tomography (CT) positivity in COVID-19 patients was statistically significant in the thrombotic subgroup (p < 0.05). FVL prevalence, CT positivity rate, history of thrombosis, and pulmonary thromboembolism complication were found to be higher in deceased COVID-19 patients (p < 0.05). Disease severity was mainly affected by FVL and not related to genotypes at the Prothrombin mutations. Overall, disease severity and development of thrombosis in COVID-19 are mainly affected by the variation within the FVL gene. Possible FVL mutation should be investigated in COVID-19 patients and appropriate treatment should be started earlier in FVL-positive patients.en_US
dc.identifier.doi10.1002/jmv.28457
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue2en_US
dc.identifier.pmid36597901en_US
dc.identifier.scopus2-s2.0-85148657613en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.28457
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20170
dc.identifier.volume95en_US
dc.identifier.wosWOS:001034949300128en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectFactor V Leidenen_US
dc.subjectProthrombinen_US
dc.subjectThrombophiliaen_US
dc.subjectSars-Cov-2 Infectionen_US
dc.subjectFrequencyen_US
dc.subjectPopulationen_US
dc.subjectG20210aen_US
dc.titleContribution of genotypes in Prothrombin and Factor V Leiden to COVID-19 and disease severity in patients at high risk for hereditary thrombophiliaen_US
dc.typeArticleen_US

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