The effects of fat distribution and some adipokines on insulin resistance in subjects with prediabetes

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dc.authoridbilir, bulent/0000-0003-2112-4056
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.contributor.authorBilir, Betul Ekiz
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorTuncbilek, Nermin
dc.contributor.authorDemir, Ahmet Muzaffer
dc.contributor.authorPolat, Ahmet
dc.contributor.authorBilir, Bulent
dc.date.accessioned2024-06-12T11:07:11Z
dc.date.available2024-06-12T11:07:11Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: The risk of developing insulin resistance and metabolic syndrome is particularly high in central obesity. In this study we evaluated the effects of fat distribution and some adipokines on insulin resistance in prediabetic patients. Material and methods: Eighty-seven age- and sex-matched patients were divided into three groups according to their 75-gram oral glucose tolerance test results as follows: impaired fasting glucose group, impaired glucose tolerance group, and normal glucose tolerance group. Fasting insulin levels were measured. Homeostatic model assessment of insulin resistance was calculated. Body fat mass measurements were assessed by bioelectric impedance analyser and abdominal fat thicknesses (subcutaneous, visceral, and preperitoneal) by ultrasonography. The fasting serum levels of several adipokines [adiponectin, leptin, resistin, vaspin, visfatin, retinol-binding protein-4 (RBP-4), tumour necrosis factor-alpha (TNF-alpha)] were measured by ELISA method. Results: The mean body mass index, fat mass measurements, and abdominal fat thicknesses of the groups were similar. There were no differences between groups in terms of the mean fasting insulin, vaspin, RBP-4, leptin, resistin, and TNF-alpha. In comparison of the prediabetic and normal groups, the levels of adiponectin (p < 0.001) and visfatin (p < 0.001) were lower in the prediabetic group. Furthermore, we found that high body mass index (p < 0.01) and fat mass (p < 0.01) and low adiponectin (p < 0.05) levels have roles in the development of insulin resistance in the prediabetic group. Conclusions: We suggested that in the prediabetic period not only obesity but also decreased adiponectin levels play some role in the pathogenesis of insulin resistance.en_US
dc.identifier.doi10.5603/EP.a2016.0023
dc.identifier.endpage282en_US
dc.identifier.issn0423-104X
dc.identifier.issue3en_US
dc.identifier.pmid26884292en_US
dc.identifier.scopus2-s2.0-84976902720en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.5603/EP.a2016.0023
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21948
dc.identifier.volume67en_US
dc.identifier.wosWOS:000380102000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofEndokrynologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin Resistanceen_US
dc.subjectAdipokineen_US
dc.subjectFat Distributionen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectGlucose-Toleranceen_US
dc.subjectDiabetes-Mellitusen_US
dc.subjectObese-Patientsen_US
dc.subjectVisfatinen_US
dc.subjectSensitivityen_US
dc.subjectAssociationsen_US
dc.subjectSecretionen_US
dc.subjectHumansen_US
dc.subjectWomenen_US
dc.titleThe effects of fat distribution and some adipokines on insulin resistance in subjects with prediabetesen_US
dc.typeArticleen_US

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