Evaluation of alveolo-capillary permeability in thyrotoxicosis using Tc-99m DTPA aerosol scintigraphy

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dc.authoridgültekin, aziz/0000-0002-0311-8077
dc.authorwosidgültekin, aziz/Q-9820-2018
dc.contributor.authorGültekin, A
dc.contributor.authorYüksel, M
dc.contributor.authorMert, S
dc.contributor.authorBerkarda, F
dc.date.accessioned2024-06-12T11:16:26Z
dc.date.available2024-06-12T11:16:26Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description15th Annual Congress of the European-Association-of-Nuclear-Medicine -- 2002 -- VIENNA, AUSTRIAen_US
dc.description.abstractSurfactant secreted from type II pneumocytes plays an important role in alveolo-capillary permeability. In thyrotoxicosis, high levels of T3 receptors detected at these cells might affect the alveolocapillary permeability due to increased serum thyroid hormone levels. The results by CO-diffusion capacity measurement in thyrotoxicosis are conflicting. Changes in alveolo-capillary membrane permeability resulting from thyrotoxicosis are not well established yet. This prompted us to investigate the alveolo-capillary permeability in thyrotoxic patients in comparison with CO-diffusing capacity. For this aim twenty-two non-smoking thyrotoxic patients (before treatment) and fifteen healthy voluntary controls underwent Tc-99m-DTPA aerosol scintigraphy. CO-diffusing and pulmonary function tests were performed in all subjects. After ventilation of radiotracer through a nebulizer for 15 minutes, 30 dynamic images (1 frame/minute) were taken from both lungs. ROI's were drawn over both lung areas, and the time-activity curves were generated. Then clearance half time (CT1/2) for radioaerosol was obtained. CT1/2 of thyrotoxic patients did not differ from that of the controls: 77.9 +/- 25.9 min vs. 79.4 +/- 22.3 min; p > 0.05. Similar result was found for CO-diffusion parameters. Also there was no significant correlation between CT1/2 and CO-diffusion parameters. We concluded that in patients with thyrotoxicosis, the alveolo-capillary permeability is unaffected. Further experimental research is needed to establish the possible effects of thyroid hormones on alveolo-capillary membrane.en_US
dc.description.sponsorshipEuropean Assoc Nucl Meden_US
dc.identifier.doi10.1007/BF02984604
dc.identifier.endpage196en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue3en_US
dc.identifier.pmid15981671en_US
dc.identifier.scopus2-s2.0-21044435699en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.1007/BF02984604
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24304
dc.identifier.volume19en_US
dc.identifier.wosWOS:000229687800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThyrotoxicosisen_US
dc.subjectAlveolo-Capillary Permeabilityen_US
dc.subjectTc-99m DTPAen_US
dc.subjectAerosol Scintigraphyen_US
dc.subjectEpithelial Permeabilityen_US
dc.subjectLungen_US
dc.subjectClearanceen_US
dc.subjectHyperthyroidismen_US
dc.titleEvaluation of alveolo-capillary permeability in thyrotoxicosis using Tc-99m DTPA aerosol scintigraphyen_US
dc.typeConference Objecten_US

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