QUERCETIN AMELIORATES THE STREPTOZOTOCIN-INDUCED DIABETIC RENAL INJURY BY INHIBITING APOPTOSIS

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dc.contributor.authorSozuer, Emine Ceyda
dc.contributor.authorTopcu Tarladacalisir, Yeter
dc.date.accessioned2024-06-12T11:15:40Z
dc.date.available2024-06-12T11:15:40Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractDiabetes mellitus is an important health problem worldwide due to its frequency and complications. In this study, the protective effect of quercetin on the apoptotic changes of rat kidney in the early stages of diabetes induced by streptozotocin (STZ) was evaluated. Rats are divided into 3 groups as control, diabetic and diabetic+quercetin groups. STZ was applied as a single dose of 50 mg/kg intraperitoneal (i.p.) to diabetic and diabetic+quercetin groups. Quercetin was given at 30 mg/kg i.p. once a day for 15 days, 48 hours after induction of diabetes. At the end of quercetin treatment, all animals were sacrificed and kidneys were harvested and weighed. The terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay (TUNEL) for apoptosis was performed and evaluated renal histopathology. The induction of diabetes via STZ caused a significant increase in blood glucose levels, the index of glomerulosclerosis, the histopathologic score, the number of TUNEL positive tubular and glomerular cells. Quercetin treatment lowered blood glucose levels, prevented renal cell apoptotic changes and histopathological alterations in diabetic rat kidney. The findings of the study suggested that quercetin may be useful in preventing diabetic nephropathy by regulating renal apoptotic changes that occur in the early stages of diabetes.en_US
dc.description.sponsorshipTrakya University Scientific Research Committee [2017/15]en_US
dc.description.sponsorshipThe study was supported by the Trakya University Scientific Research Committee with project number 2017/15.en_US
dc.identifier.doi10.23902/trkjnat.879200
dc.identifier.endpage138en_US
dc.identifier.issn2147-0294
dc.identifier.issn2528-9691
dc.identifier.issue2en_US
dc.identifier.startpage131en_US
dc.identifier.trdizinid495146en_US
dc.identifier.urihttps://doi.org/10.23902/trkjnat.879200
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/495146
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24026
dc.identifier.volume22en_US
dc.identifier.wosWOS:000708959600002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTrakya Univ Balkan Yerlesesi Enstituler Binasien_US
dc.relation.ispartofTrakya University Journal Of Natural Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptozotocinen_US
dc.subjectQuercetinen_US
dc.subjectNephropathyen_US
dc.subjectApoptosisen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectRaten_US
dc.subjectTubular Epithelial-Cellsen_US
dc.subjectAdvanced Glycation Endproductsen_US
dc.subjectOxidative Stressen_US
dc.subjectPodocyte Apoptosisen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectGlucoseen_US
dc.subjectNephropathyen_US
dc.subjectProliferationen_US
dc.subjectPathogenesisen_US
dc.subjectInflammationen_US
dc.titleQUERCETIN AMELIORATES THE STREPTOZOTOCIN-INDUCED DIABETIC RENAL INJURY BY INHIBITING APOPTOSISen_US
dc.typeArticleen_US

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Trakya University Journal of Natural Sciences