The effects of taurine, melatonin and acetylcysteine on nitric oxide, lipid peroxidation and some antioxidants in cadmium induced liver injury

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErbas, Hakan
dc.contributor.authorKaymak, Kadir
dc.date.accessioned2024-06-12T10:50:20Z
dc.date.available2024-06-12T10:50:20Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Our aim was to investigate both the potential protective and therapeutic effects of taurine, melatonin and acetylcysteine in cadmium induced liver injury. Material and Methods: Ninety male Spraque Dawley rats were divided into nine groups. For the three months treatment period, drinking water was administered to Group 1 whereas 200 ppm CdCl2 to Group 2, 200 ppm CdCl2 and 1% taurine to Group 3, 200 ppm CdCl2 and 0.02% melatonin to Group 4 and 200 ppm CdCl2 and 0.5%acetylcysteine to Group 5. Groups 6, 7, 8 and 9 received 200 ppm CdCl2 in their drinking water for 3 months. After this period, for 7 days, 4% taurine to group 7, 0.08% melatonin to Group 8 and 2% acetylcysteine to group 9 were applied. Results: In liver tissues of cadmium received rats, the levels of glutathione (GSH) and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were decreased. Thiobarbituric acid reactive substances (TBARS), nitric oxide (NO) and inducible nitric oxide synthase (iNOS) activities were increased. While, taurine, melatonin and acetylcysteine increased GSH levels, SOD and GPx activities, it decreased TBARS, NO and iNOS activities. Conclusion: Taurine, melatonin and acetylcysteine may have both protective and therapeutic effects in cadmium induced liver injuries.en_US
dc.identifier.endpage96en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-34250763124en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17972
dc.identifier.volume29en_US
dc.identifier.wosWOS:000421141000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcysteineen_US
dc.subjectAntioxidantsen_US
dc.subjectCadmiumen_US
dc.subjectMelatoninen_US
dc.subjectTaurineen_US
dc.subjectOxidative Stressen_US
dc.subjectKidneyen_US
dc.subjectInductionen_US
dc.subjectToxicityen_US
dc.subjectEnzymesen_US
dc.subjectAssayen_US
dc.titleThe effects of taurine, melatonin and acetylcysteine on nitric oxide, lipid peroxidation and some antioxidants in cadmium induced liver injuryen_US
dc.typeArticleen_US

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