The Relation Between Serum Levels of Insulin-like Growth Factor-1 and Bronchopulmonary Dysplasia

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dc.authorwosidDuran, Rıdvan/C-1065-2015
dc.contributor.authorCiftdemir, Nukhet Aladag
dc.contributor.authorAcunas, Betul
dc.contributor.authorOzbek, Ulfet Vatansever
dc.contributor.authorDuran, Ridvan
dc.date.accessioned2024-06-12T10:55:19Z
dc.date.available2024-06-12T10:55:19Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The etiology of bronchopulmonary dysplasia (BPD) which is the most important unwanted consequence of premature delivery at long term has not been determined clearly yet.. Insulin-like growth factor-1 (IGF-1) is involved in both prenatal and postnatal lung growth. Our aim is to characterize postnatal changes in serum IGF-1 in relation to development of BPD in preterms. Method: Sixty-seven preterm newborns were evaluated prospectively in order to investigate independent risk factors associated with BPD and to determine the relation between serum IGF-1 levels and BPD. Infants included in the study were divided into two groups as those that developed (Group 1; n=12) and did not develop BPD (Group 2; n=55). Serum IGF-1 levels were measured from venous blood samples of each infant on days 1, 7, 14 and 28 after birth. Results: When the variables showing significant differences in the comparisons between the two groups were evaluated in different logistic regression models, according to the most significant model; presence of chorioamnionitis did not contribute significantly to the development of BPD. It was found that 1 week increase in gestational week reduced the risk of BPD formation by half, while the presence of RDS or sepsis increased the risk of development of BPD by 14.4, and 9.6 times, respectively. ROC analysis with serial measurements of IGF-1 showed that IGF-1 was not a determinant of BPD development. Conclusion: We could not find any relation between development of BPD and serum IGF-1 levels in our study and concluded that the smaller number of newborn who developed BPD could have limited the evaluation of this association.en_US
dc.identifier.doi10.5222/buchd.2019.39306
dc.identifier.endpage154en_US
dc.identifier.issn2146-2372
dc.identifier.issn1309-9566
dc.identifier.issue2en_US
dc.identifier.startpage149en_US
dc.identifier.trdizinid319244en_US
dc.identifier.urihttps://doi.org/10.5222/buchd.2019.39306
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/319244
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19380
dc.identifier.volume9en_US
dc.identifier.wosWOS:000477890900012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherDr Behcet Uz Cocuk Hastaliklari Ve Cerrahisien_US
dc.relation.ispartofIzmir Dr Behcet Uz Cocuk Hastanesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBronchopulmonary Dysplasiaen_US
dc.subjectInsulin-Like Growth Factor-1en_US
dc.subjectPretermen_US
dc.subjectChronic Lung-Diseaseen_US
dc.subjectBirth-Weight Infantsen_US
dc.subjectPreterm Infantsen_US
dc.subjectIgf-Ien_US
dc.subjectTracheal Aspirateen_US
dc.subjectCytokine Levelsen_US
dc.subjectRetinopathyen_US
dc.subjectChorioamnionitisen_US
dc.subjectInflammationen_US
dc.subjectBiomarkersen_US
dc.titleThe Relation Between Serum Levels of Insulin-like Growth Factor-1 and Bronchopulmonary Dysplasiaen_US
dc.typeArticleen_US

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