Preventive Effect of Phosphodiesterase Inhibitor Pentoxifylline Against Medication-Related Osteonecrosis of the Jaw: An Animal Study

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dc.authoridUSLU, UNAL/0000-0003-3953-7131
dc.authoridYalçın Ülker, Gül Merve/0000-0002-7438-5834
dc.authoridDUYGU, Gonca/0000-0002-5564-5776
dc.authoridCumbul, Alev/0000-0002-9491-8220
dc.authorwosidUSLU, UNAL/H-1226-2011
dc.authorwosidYalçın Ülker, Gül Merve/IUP-8264-2023
dc.authorwosidCUMBUL, Alev/H-3991-2011
dc.contributor.authorYalcin-Ulker, Gul Merve
dc.contributor.authorCumbul, Alev
dc.contributor.authorDuygu-Capar, Gonca
dc.contributor.authorUslu, Unal
dc.contributor.authorSencift, Kemal
dc.date.accessioned2024-06-12T11:17:43Z
dc.date.available2024-06-12T11:17:43Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of this experimental study was to investigate the prophylactic effect of pentoxifylline (PTX) on medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods: Female Sprague-Dawley rats (n=33) received zoledronic acid (ZA) for 8 weeks to create an osteonecrosis model. The left mandibular second molars were extracted and the recovery period lasted 8 weeks before sacrifice. PTX was intraperitoneally administered to prevent MRONJ. The specimens were histopathologically and histomorphometrically evaluated. Results: Histomorphometrically, between the control and ZA groups, there was no statistically significant difference in total bone volume (P=.999), but there was a statistically significant difference in bone ratio in the extraction sockets (P<.001). A comparison of the bone ratio of the ZA group with the ZA/PTX group (PTX administered after extraction) showed no statistically significant difference (P=.69), but there was a statistically significant difference with the ZA/PTX/PTX group (PTX administered before and after extraction; P=.008). Histopathologically, between the control and ZA groups, there were statistically significant differences for inflammation (P=.013), vascularization (P=.022), hemorrhage (P=.025), and regeneration (P=.008). Between the ZA and ZA/PTX groups, there were no statistically significant differences for inflammation (P=.536), vascularization (P=.642), hemorrhage (P=.765), and regeneration (P=.127). Between the ZA and ZA/PTX/PTX groups, there were statistically significant differences for inflammation (P=.017), vascularization (P=.04), hemorrhage (P=.044), and regeneration (P=.04). Conclusion: In this experimental model of MRONJ, it might be concluded that although PTX, given after tooth extraction, improves new bone formation that positively affects bone healing, it is not prophylactic. However, PTX given before tooth extraction is prophylactic. Therefore, PTX might affect healing in a positive way by optimizing the inflammatory response. (C) 2017 American Association of Oral and Maxillofacial Surgeonsen_US
dc.identifier.doi10.1016/j.joms.2017.04.017
dc.identifier.endpage2368en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue11en_US
dc.identifier.pmid28529150en_US
dc.identifier.scopus2-s2.0-85020931523en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2354en_US
dc.identifier.urihttps://doi.org/10.1016/j.joms.2017.04.017
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24809
dc.identifier.volume75en_US
dc.identifier.wosWOS:000415174300012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Oral And Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBisphosphonate-Related Osteonecrosisen_US
dc.subjectSurgeons Position Paperen_US
dc.subjectZoledronic Aciden_US
dc.subjectTnf-Alphaen_US
dc.subjectCancer-Patientsen_US
dc.subjectAmerican Associationen_US
dc.subjectOral Bisphosphonatesen_US
dc.subjectDental Extractionsen_US
dc.subjectRisk-Factorsen_US
dc.subjectIn-Vitroen_US
dc.titlePreventive Effect of Phosphodiesterase Inhibitor Pentoxifylline Against Medication-Related Osteonecrosis of the Jaw: An Animal Studyen_US
dc.typeArticleen_US

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