Synthesis of macrocyclization cyclophanes and their metal complexes, characterization and antimicrobial activity

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dc.authorscopusid6507892320
dc.authorscopusid58155544000
dc.authorscopusid9735216100
dc.contributor.authorTürkyilmaz M.
dc.contributor.authorDönmez M.
dc.contributor.authorAteş M.
dc.date.accessioned2024-06-12T10:26:24Z
dc.date.available2024-06-12T10:26:24Z
dc.date.issued2023
dc.description.abstractDue to their chemical properties, cyclophane-type compounds constitute an interesting organic chemistry class. In the structure of all cyclic compounds, macrocyclization is the most critical issue for high-efficiency synthesis. Especially with a small cyclophane structure, the experimental steps are more complicated than with a prominent cyclophane structure. In this manuscript, three different material groups were applied to synthesize silver cyclophane compounds for smart drug properties. In the first material group, 5,6-dimetil-1H-benzo[d] imidazole (1) and 2,6-bis(chloromethyl)pyridine (2) were reacted to form 5,6-dimethyl-1-((6-((5,6-dimethyl-1H-benzo[d]imidazole-1-il)methyl)pyridine-2-il)methyl)-1H-benzo[d] imidazole compound (3). In the second material group, ethyl 2-bromoacetate (4) reacted to different nitrogen atoms of the cyclophane compound to form a symmetric carbene com-pound, which is water-soluble (5). In the third material group, the silver (I) and palladium (II) metal complexes were synthesized due to the reaction with silver(I) oxide (6) and palladium (II) chloride (7). Antimicrobial activities of the carbene compounds and silver and palladium complexes (5, 6, and 7) were investigated against bacteria and fungal in more detail. Silver (I) complex (6) shows an antimicrobial agent when mixed with microorganisms, such as Gram-positive, Gram-negative, and fungal, but this property has not been observed in the palladium (II)-carbene complex (7). © 2023, Kare Publishing. All rights reserved.en_US
dc.description.sponsorshipTrakya Üniversitesi: TUBAP-2014-106en_US
dc.description.sponsorshipThis study received financial support from the Trakya University Research Fund (TUBAP-2014-106).en_US
dc.identifier.doi10.47481/jscmt.1253033
dc.identifier.endpage34en_US
dc.identifier.issn2458-973X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85167815247en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage27en_US
dc.identifier.trdizinid1161719en_US
dc.identifier.urihttps://doi.org/10.47481/jscmt.1253033
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1161719
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16831
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofJournal of Sustainable Construction Materials and Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial Agent; Carbene; Cyclophanes; Palladium (Ii)-Nhc Complex; Silver (I)-Nhc Complexen_US
dc.titleSynthesis of macrocyclization cyclophanes and their metal complexes, characterization and antimicrobial activityen_US
dc.typeArticleen_US

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