Gamma probes and their use in tumor detection in colorectal cancer
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The purpose of this article is to summarize the role of gamma probes in intraoperative tumor detection in patients with colorectal cancer (CRC), as well as provide basic information about the physical and practical characteristics of the gamma probes, and the radiopharmaceuticals used in gamma probe tumor detection. In a significant portion of these studies, radiolabeled monoclonal antibodies (Mabs), particularly 125I labeled B72.3 Mab that binds to the TAG-72 antigen, have been used to target tumor. Studies have reported that intraoperative gamma probe radioimmunodetection helps surgeons to localize primary tumor, clearly delineate its resection margins and provide immediate intraoperative staging. Studies also have emphasized the value of intraoperative gamma probe radioimmunodetection in defining the extent of tumor recurrence and finding sub-clinical occult tumors which would assure the surgeons that they have completely removed the tumor burden. However, intraoperative gamma probe radioimmunodetection has not been widely adapted among surgeons because of some constraints associated with this technique. The main difficulty with this technique is the long period of waiting time between Mab injection and surgery. The technique is also laborious and costly. In recent years, Fluorine-18-2-fluoro-2-deoxy-D-glucose (18F-FDG) use in gamma probe tumor detection surgery has renewed interest among surgeons. Preliminary studies during surgery have demonstrated that use of FDG in gamma probe tumor detection during surgery is feasible and useful. © 2008 Sarikaya et al; licensee BioMed Central Ltd.
Açıklama
Anahtar Kelimeler
Fluorodeoxyglucose F 18; Indium 111; Iodine 123; Iodine 125; Iodine 131; Methoxy Isobutyl Isonitrile Technetium Tc 99m; Monoclonal Antibody B.72.3 I 131; Pentetreotide In 111; Radiopharmaceutical Agent; Technetium 99m; Thallium 201; Abdominal Surgery; Cancer Staging; Cancer Surgery; Clinical Trial; Colorectal Cancer; Drug Uptake; Human; Immunodetection; Intraoperative Period; Laparotomy; Nonhuman; Positron Emission Tomography; Radiation Absorption; Review; Scintiscanning; Sensitivity And Specificity; Survival Rate; Tumor Localization; Tumor Recurrence; Tumor Volume
Kaynak
International Seminars in Surgical Oncology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
5
