Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidBarutcu, Ahmet/HKE-7359-2023
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorBarutcu, A.
dc.contributor.authorAksu, F.
dc.contributor.authorOzcelik, F.
dc.contributor.authorBarutcu, C. A. E.
dc.contributor.authorUmit, G. E.
dc.contributor.authorPamuk, O. N.
dc.contributor.authorAltun, A.
dc.date.accessioned2024-06-12T10:51:56Z
dc.date.available2024-06-12T10:51:56Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n=50) and control group (n = 30). They were categorized into four subgroups: anticardiolipin antibodies (aCL) (+) (n = 14) and aCL (-) (n = 36); systemic lupus erythematosus disease activity index (SLEDAI) >= 6 (n = 15) and SLEDAI < 6 (n = 35); disease period >= 5 years (n = 21) and disease period < 5 years (n = 29); major organ involvement (+) (n = 19), major organ involvement (-) (n = 31). The ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E') for the study group was found to be higher than the control (p < 0.01). Systolic septal motion velocity (Ssm) was lower in the study group compared with the control (p < 0.01). Left atrium (LA) dimension was greater in the study group than the control (p < 0.01). Ssm was found to be lower in the aCL (+) patients compared with the control and aCL (-) groups (p < 0.01, p < 0.05, respectively). LA dimension was greater in the aCL (+) and (-) groups compared with the control, (p < 0.01, p < 0.05, respectively) and aCL groups compared with each other (p < 0.05). The E/E' ratio for the aCL (+) and (-) groups was found to be greater than the control (p < 0.05). In the study, both the Ssm and the late diastolic septal velocity (sA') was found to be lower in the SLEDAI >= 6 group compared with SLEDAI < 6 group, (p < 0.001, p < 0.05, respectively). LA dimension was statistically greater in the SLEDAI >= 6 group compared with the SLEDAI < 6 group (p < 0.001). E' and early diastolic septal velocity (sE') were statistically lower in the disease period > 5 years group compared with the disease period < 5 years group (p < 0.01, p < 0.05, respectively). Carrying out regular scans with TTE image of SLE patients is important in order to identify early cardiac involvement during monitoring and treatment. Identifying early cardiac involvement in SLE may lead to a reduction in mortality and morbidity rates.en_US
dc.identifier.doi10.1177/0961203315570164
dc.identifier.endpage1028en_US
dc.identifier.issn0961-2033
dc.identifier.issn1477-0962
dc.identifier.issue10en_US
dc.identifier.pmid25697770en_US
dc.identifier.scopus2-s2.0-84938806824en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1019en_US
dc.identifier.urihttps://doi.org/10.1177/0961203315570164
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18538
dc.identifier.volume24en_US
dc.identifier.wosWOS:000359402200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofLupusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticardiolipin Antibodyen_US
dc.subjectTissue Doppleren_US
dc.subjectDiastolic Dysfunctionen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectVentricular Diastolic Functionen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectRisk-Factorsen_US
dc.subjectAccelerated Atherosclerosisen_US
dc.subjectAntiphospholipid Antibodiesen_US
dc.subjectTissue Doppleren_US
dc.subjectEchocardiographyen_US
dc.subjectAbnormalitiesen_US
dc.subjectAssociationen_US
dc.titleEvaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodiesen_US
dc.typeArticleen_US

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