Overt gastrointestinal bleeding in haematologic neoplasms

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dc.authoridHaznedaroglu, Ibrahim C./0000-0001-8028-9462;
dc.authorwosidHaznedaroglu, Ibrahim C./AAB-2114-2019
dc.authorwosidBuyukasik, Yahya/AAJ-3228-2020
dc.contributor.authorSoylu, AR
dc.contributor.authorBuyukasik, Y
dc.contributor.authorCetiner, D
dc.contributor.authorBuyukasik, NS
dc.contributor.authorKoca, E
dc.contributor.authorHaznedaroglu, IC
dc.contributor.authorOzcebe, OI
dc.date.accessioned2024-06-12T10:59:55Z
dc.date.available2024-06-12T10:59:55Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and aim. Patients with acute leukaemia suffer from various haemorrhages, most frequently due to thrombocytopenia. We could not reach any information regarding the frequency of gastrointestinal bleeding in acute leukaemia and decided to search this complication in patients with acute and chronic leukaemias and myeloproliferative disorders, retrospectively. Patients and methods. During a 6-year period, 291 patients with acute leukaemia, 52 patients with chronic leukaemia and 108 patients with myeloproliferative disorders had been followed. Thirty-two cases of overt gastrointestinal haemorrhage episodes (25 upper, 7 lower) were observed during the mentioned period. Results. The frequency of bleeding episodes was 7.1% (32/451) in haematologic malignancies as a whole, 5.8% (17/291) for acute leukaemia, 1.9% (1/52) for chronic leukaemia and 13% (14/108) for myeloproliferative disorders. If the patients with myeloproliferative disorders in blastic phase were analysed seperately, the ratio was 30% (6/20). Oesophagogastroduodenoscopy, which could be performed in 8 of 25 upper gastrointestinal haemorrhage, episodes, revealed erosive gastritis in five patients and duodenal ulcers in three patients. Neutropenic enterocolitis was the underlying cause in all of the seven patients with lower. gastrointestinal haemorhage. Five out of the seven patients had acute leukaemia. In 7 bleeding attacks, out of 32, the ultimate result was death. Generally, the haemorrhage was only a contributing cause of mortality. All of the mortality cases were patients with acute leukaemia. Conclusion. Especially, the patients with myeloproliferative disorders are prone to develop gastrointestinal haemorrhage. The manifestation is generally as upper gastrointestinal bleeding due to gastric erosions and duodenal ulcers. Lower gastrointestinal bleeding is frequently a problem of the patients with acute leukaemia. It is commonly a sign of neutropenic enterocolitis. (C) 2005 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.dld.2005.07.017
dc.identifier.endpage922en_US
dc.identifier.issn1590-8658
dc.identifier.issue12en_US
dc.identifier.pmid16243010en_US
dc.identifier.scopus2-s2.0-33644876102en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage917en_US
dc.identifier.urihttps://doi.org/10.1016/j.dld.2005.07.017
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20621
dc.identifier.volume37en_US
dc.identifier.wosWOS:000234038700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPacini Editoreen_US
dc.relation.ispartofDigestive And Liver Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDuodenal Ulceren_US
dc.subjectGastric Erosionen_US
dc.subjectGastrointestinal Haemorrhageen_US
dc.subjectHaematologic Neoplasmsen_US
dc.subjectNeutropenic Enterocolitisen_US
dc.subjectMyeloproliferative Disordersen_US
dc.subjectNeutropenic Enterocolitisen_US
dc.subjectMyelogenous Leukemiaen_US
dc.subjectCancer-Patienten_US
dc.subjectHemorrhageen_US
dc.subjectTransplantationen_US
dc.subjectComplicationsen_US
dc.subjectManagementen_US
dc.subjectHistamineen_US
dc.subjectChildrenen_US
dc.titleOvert gastrointestinal bleeding in haematologic neoplasmsen_US
dc.typeArticleen_US

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