Effects of propofol and midazolam infusions on serum lipid and glucose levels in hyperlipidemic patients undergoing coronary artery bypass surgery

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dc.authorscopusid56185881800
dc.authorscopusid14032022300
dc.authorscopusid56185401100
dc.authorscopusid55834600600
dc.authorscopusid6505802281
dc.contributor.authorAcartürk H.
dc.contributor.authorÖztekin I.
dc.contributor.authorÖztek S.D.
dc.contributor.authorIşsever H.
dc.contributor.authorCanik S.
dc.date.accessioned2024-06-12T10:26:33Z
dc.date.available2024-06-12T10:26:33Z
dc.date.issued2014
dc.description.abstractObjective: Propofol has been accused for increasing plasma lipid levels during continuous infusion due to its lipid content. We aimed to show the effect and the risk of propofol infusion on plasma lipid and glucose levels in patients with hyperlipidemia undergoing coronary artery bypass graft surgery (CABG), and to compare them with a midazolam used control group. Material and Methods: In this randomized controlled study, 15 patients in the propofol group had anesthesia induction with intravenous propofol 1%, 2 mg/kg, fentanyl 10-15 mcg/kg, pancuronium 0.1 mg/kg, and the anesthesia was maintained with 1% 2-5 mg/kg/h propofol infusion, fentanyl 5-10 mcg/kg/hr, and an hourly pancuronium dose of 0.03 mg/kg The anesthetia management of 15 patients in midazolam group included induction with midazolam 0.1 mg/kg, fentanyl 10-15 mcg/kg, pancuronium 0.1 mg/kg, and infusion of midazolam 0.05-0.07 mg/kg/hr, fentanyl 5-10 mcg/kg/hr, and an hourly pancuronium dose of 0.03 mg/kg Plasma lipid [total cholesterol (CHL), triglyceride (TRG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL)] and glucose concentrations were measured in both groups perioperatively, at seven different time points until 72 hours after the operation. Results: The decreases of TRG and HDL levels were statistically significant in the midazolam group. There were no significant differences for the decreases in CHL, LDL and VLDL levels between the groups. In both groups, plasma glucose levels increased significantly, independent from the propofol and midazolam infusions. Conclusion: We observed that propofol and midazolam anesthesia used in patients with hyperlipidemia undergoing to CABG did not have any effect on plasma lipid or glucose levels. © 2014 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2014-38844
dc.identifier.endpage272en_US
dc.identifier.issn1300-0292
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84901654778en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2014-38844
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16883
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFamilial Combined; Glucose; Hyperlipidemia; Lipids; Midazolam; Propofolen_US
dc.subjectAtropine; Cholesterol; Diazepam; Fentanyl; High Density Lipoprotein; Low Density Lipoprotein; Midazolam; Pancuronium; Propofol; Triacylglycerol; Very Low Density Lipoprotein; Adult; Aged; Arterial Oxygen Saturation; Article; Bedtime Dosage; Body Mass; Clinical Article; Controlled Study; Coronary Artery Bypass Surgery; Female; Glucose Blood Level; Hemodynamics; Human; Hyperlipidemia; Lipid Blood Level; Male; Muscle Relaxation; Prospective Study; Randomized Controlled Trialen_US
dc.titleEffects of propofol and midazolam infusions on serum lipid and glucose levels in hyperlipidemic patients undergoing coronary artery bypass surgeryen_US
dc.title.alternativeKoroner arter baypas ameliyati{dotless} geçiren hiperlipidemili hastalarda propofol ve midazolam Infüzyonlari{dotless}ni{dotless}n serum lipidleri ve glukoz düzeyleri üzerine etkilerien_US
dc.typeArticleen_US

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