Evaluation of prognostic factors in localized high-grade undifferentiated pleomorphic sarcoma: report of a multi-institutional experience of Anatolian Society of Medical Oncology

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dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authoridÖksüzoğlu Çakmak, Ömür Berna/0000-0002-2756-8646
dc.authoridaksoy, asude/0000-0002-5609-9658
dc.authoridAliustaoglu, Mehmet/0000-0003-0287-0766
dc.authorwosidGumus, Mahmut/HTO-4176-2023
dc.authorwosidERASLAN, EMRAH/HPC-1851-2023
dc.authorwosidmenekşe, serkan/HNP-3265-2023
dc.authorwosidZengin, Nurullah/KBQ-0049-2024
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.authorwosidÖksüzoğlu Çakmak, Ömür Berna/HKN-6428-2023
dc.authorwosidozcelik, melike/AAS-7557-2020
dc.contributor.authorOzcelik, Melike
dc.contributor.authorSeker, Mesut
dc.contributor.authorEraslan, Emrah
dc.contributor.authorKoca, Sinan
dc.contributor.authorYazilitas, Dogan
dc.contributor.authorErcelep, Ozlem
dc.contributor.authorOzaslan, Ersin
dc.date.accessioned2024-06-12T11:03:19Z
dc.date.available2024-06-12T11:03:19Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMost data on prognostic factors for patients with high-grade undifferentiated pleomorphic sarcoma (HGUPS) is obtained from analyses of soft tissue sarcomas. The purpose of this study was to evaluate the clinicopathologic features and their impact on outcomes specifically in patients diagnosed with HGUPS. In this multicenter trial, we retrospectively analyzed 112 patients who were diagnosed and treated at 12 different institutions in Turkey. We collected data concerning the patients, tumor characteristics, and treatment modalities. There were 69 males (61.6 %) and 43 females (38.4 %). Median age was 56 years (19-90). The most common anatomic site of tumor origin was the upper extremity. Pleomorphic variant was the predominant histological subtype. Median tumor size was 8.2 cm (0.6-30 cm). Tumors were mainly deeply seated (57.1 %). Fifty-seven patients (50.9 %) were stage II and the remainder were stage III at the time of diagnosis. Median follow-up was 30 months (2-160). The primary site of distant metastasis was the lung (73.5 %) and the second most common site was the liver (11.7 %). The 5-year overall survival, distant metastasis-free survival, and local recurrence-free survival rates were 56.3, 53.4, and 67.2 %, respectively. Multivariate analysis showed that Eastern Cooperative Oncology Group (ECOG) performance score of II (p = 0.033), deep tumor location (p = 0.000), and development of distant metastasis (p = 0.004) were negatively correlated with overall survival, and perioperative radiotherapy and negative microscopic margins were significant factors for local control rates (p = 0.000 for each). Deep tumor location (p = 0.003) was the only adverse factor related to distant metastasis-free survival. Deep tumor location, ECOG performance score of II, and development of distant metastasis carry a poor prognostic implication on overall survival. These will aid clinicians in predicting survival and treatment decision.en_US
dc.identifier.doi10.1007/s13277-015-4359-1
dc.identifier.endpage5237en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue4en_US
dc.identifier.pmid26553363en_US
dc.identifier.scopus2-s2.0-84946761132en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5231en_US
dc.identifier.urihttps://doi.org/10.1007/s13277-015-4359-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21593
dc.identifier.volume37en_US
dc.identifier.wosWOS:000374904500105en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-Grade Undifferentiated Pleomorphic Sarcomaen_US
dc.subjectMalignant Fibrous Histiocytomaen_US
dc.subjectPrognostic Factorsen_US
dc.subjectSoft Tissue Sarcomaen_US
dc.subjectMalignant Fibrous Histiocytomaen_US
dc.subjectSoft-Tissue Sarcomasen_US
dc.subjectAdjuvant Chemotherapyen_US
dc.subjectSurgical-Treatmenten_US
dc.subjectExtremitiesen_US
dc.subjectClassificationen_US
dc.subjectRecurrenceen_US
dc.subjectExpressionen_US
dc.subjectTherapyen_US
dc.subjectUpdateen_US
dc.titleEvaluation of prognostic factors in localized high-grade undifferentiated pleomorphic sarcoma: report of a multi-institutional experience of Anatolian Society of Medical Oncologyen_US
dc.typeArticleen_US

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