The effects of L-carnitine on acetaminophen induced hepatotoxicity in rats

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.contributor.authorAktas, Ozgur
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorOzgun, Gulben Sayilan
dc.contributor.authorYalcin, Omer
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:50:19Z
dc.date.available2024-06-12T10:50:19Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the protective effect of L-carnitine against to liver damage caused by lipid peroxidation and oxidative stress in toxic hepatitis induced by acetaminophen. Materials and Methods: Wister-albino male rats were divided into three groups randomly: control, toxic hepatitis, and L-carnitine groups. To introduce a toxic hepatitis, single dose of acetaminophen (300 mg/kg) dissolved in warm saline was given intraperitoneally to toxic hepatitis and L-carnitine groups. A single dose of L-carnitine (500 mg/kg) was given intraperitoneally to L-carnitine group five minutes after introducing to toxic hepatitits. A single dose of warm saline was given intraperitoneally to control group. Results: In toxic hepatitis group, serum alanine and aspartate aminotransferase and plasma and liver malondialdehyde levels were higher whereas plasma Gc-globulin, whole blood and liver glutathione levels, erythrocyte and liver catalase activities and erythrocyte glutathione peroxidase activity were lower as compared to control group. In L-carnitine group, serum alanine and aspartate aminotransferase and plasma and liver malondialdehyde levels were lower whereas whole blood and liver glutathione levels, erythrocyte and liver catalase activities and erythrocyte glutathione peroxidase activity were higher as compared to toxic hepatitis group. There was no significant change between plasma Gc-Globulin levels of these groups. Histopathological changes in toxic hepatitis group were more prominent than those found in L-carnitine group. Conclusion: L-Carnitine has a protective effect against to liver damage caused by lipid peroxidation and oxidative stress in toxic hepatitis induced by acetaminopfen in rats.en_US
dc.identifier.doi10.5505/tjb.2013.92063
dc.identifier.endpage482en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84892609350en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage475en_US
dc.identifier.urihttps://doi.org/10.5505/tjb.2013.92063
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17966
dc.identifier.volume38en_US
dc.identifier.wosWOS:000329577500016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetaminophenen_US
dc.subjectL-Carnitineen_US
dc.subjectLipid Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidantsen_US
dc.subjectLiver Damageen_US
dc.subjectAdenosyl-L-Methionineen_US
dc.subjectFree Gc-Globulinen_US
dc.subjectAntioxidant Activitiesen_US
dc.subjectHepatic Damageen_US
dc.subjectLiveren_US
dc.subjectToxicityen_US
dc.subjectParacetamolen_US
dc.subjectMechanismsen_US
dc.subjectInjuryen_US
dc.titleThe effects of L-carnitine on acetaminophen induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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