VEGF, IL-17 and IgG4 levels of patients with lung sequelae in post-COVID-19 period

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dc.authoridgullu arslan, nevra/0000-0002-1643-1978
dc.authoridYilmam, Ilker/0000-0003-4349-5771
dc.authoridgorgun, selim/0000-0001-5841-591X
dc.authorwosidgullu arslan, nevra/HHD-1360-2022
dc.authorwosidGorgun, Selim/AAM-5518-2021
dc.contributor.authorArslan, Nevra Gullu
dc.contributor.authorAksakal, Sengul
dc.contributor.authorYilmam, Ilker
dc.contributor.authorGorgun, Selim
dc.date.accessioned2024-06-12T10:58:44Z
dc.date.available2024-06-12T10:58:44Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractVEGF, IL-17 and IgG4 levels of patients with lung sequelae in post-COVID-19 period Introduction: Although the epidemiological and clinical characteristics of COVID-19 patients have been described; the pathogenesis of the disease and its long-term consequences are still unclear. Pulmonary fibrosis is one of these late outcomes. In this study we evaluated Interleukin-17 (IL-17), vascular endothelial growth factor (VEGF), and immunoglobulin G4 (IgG4) levels of COVID-19 infected patients with different clinical course and their effect on pulmonary fibrosis in post-COVID period. Materials and Methods: In total, 90 patients were evaluated. Among the patients who presented for a control visit between 3-12 weeks after acute infection; patients with signs of pulmonary sequelae radiologically (traction bronchiectasis, interseptal thickening, disorders in parenchyma architecture) were classified as Group I (n= 32), patients who recovered without sequelae radiologically as Group II (n= 32). The Control group included healthy individuals who did not have COVID-19, and was classified as Group III (n= 26). Results: The mean age in Group I was significantly higher than Group II and III (p< 0.001). There was a statistically significant difference between the VEGF and IL-17 values based on the patient group they are in (p< 0.05). Vascular endothelial growth factor values of Group I and III were significantly lower than the patients in Group II (p< 0.001). IL-17 values of Group I and II were found to be significantly lower than Group III (p= 0.005). There was no statistically significant relationship between groups in terms of IgG4 values. Conclusion: In our study, it was observed that the profibrotic effects of VEGF, IL-17, and IgG4 were not dominant in patients who recovered with pulmonary sequelae after COVID; therefore, it is thought that different mechanisms mentioned or not yet revealed may cause this outcome.en_US
dc.identifier.doi10.5578/tt.20229808
dc.identifier.endpage186en_US
dc.identifier.issn0494-1373
dc.identifier.issue2en_US
dc.identifier.pmid35785882en_US
dc.identifier.scopus2-s2.0-85133303996en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage179en_US
dc.identifier.trdizinid531238en_US
dc.identifier.urihttps://doi.org/10.5578/tt.20229808
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/531238
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20178
dc.identifier.volume70en_US
dc.identifier.wosWOS:000822096200008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.ispartofTuberkuloz Ve Toraks-Tuberculosis And Thoraxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectIL-17en_US
dc.subjectVEGFen_US
dc.subjectIgg4en_US
dc.subjectPulmonary Sequelaeen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectClinical Characteristicsen_US
dc.subjectCytokinesen_US
dc.subjectSars-Cov-2en_US
dc.subjectChemokinesen_US
dc.subjectHealthen_US
dc.subjectCellsen_US
dc.titleVEGF, IL-17 and IgG4 levels of patients with lung sequelae in post-COVID-19 perioden_US
dc.typeArticleen_US

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