New Schiff-base ligands containing thiophene terminals: Synthesis, characterization and biological activities

Basit Öğe Kaydı
dc.contributor.authorUlucam, Guhergul
dc.contributor.authorOkan, Sevket Erol
dc.contributor.authorAktas, Saban
dc.contributor.authorYenturk, Busra
dc.date.accessioned2024-06-12T10:50:12Z
dc.date.available2024-06-12T10:50:12Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSchiffbase ligand C18H24N2S2 was synthesized in the reaction of aromatic aldehyde 4-methylthiophene-2-carbaldehyde with hexane-1,6-diamine. Also, C20H28N2S2 was obtained reacting 4-methylthiophene-2-carbaldehyde with octane-1,8-diamine. The ligands have been characterized by NMR (H-1, C-13), FT-IR and mass spectroscopy. The energies and the atomic configurations of the ligands have been optimized within Density Functional Theory. The NMR and FT-IR spectra of the compounds were calculated on their optimized molecular structures, and they were compared with their corresponding experimental NMR and FT-IR spectra. The antibacterial activities of synthesized compounds were investigated by using Broth Micro-Dilution method. They were effective on Staphylococcus aureus ATCC 25923 bacteria as much as the effect created by the antibiotic in the same dose. The cytotoxic effects the ligands were pronounced on the cancer cell lines while no harm of them was observed on the healthy cells. (C) 2021 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTrakya University Research Fund [TUBAP-2016/22]en_US
dc.description.sponsorshipThis study was supported by Trakya University Research Fund with TUBAP-2016/22 project.en_US
dc.identifier.doi10.1016/j.molstruc.2021.129941
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85099636049en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2021.129941
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17905
dc.identifier.volume1230en_US
dc.identifier.wosWOS:000630326000094en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject4-Methylthiophenen_US
dc.subjectSchiffbaseen_US
dc.subjectDFT/B3LYPen_US
dc.subjectAntibacterial And Anticancer Activityen_US
dc.subjectAb-Initioen_US
dc.subjectCopper(Ii) Complexesen_US
dc.subjectAcetic-Aciden_US
dc.subjectFt-Ramanen_US
dc.subjectDften_US
dc.subjectAnticanceren_US
dc.subjectSeriesen_US
dc.titleNew Schiff-base ligands containing thiophene terminals: Synthesis, characterization and biological activitiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu