Could mesangial C3 deposition be an independent prognostic marker in immunoglobulin A nephropathy?

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dc.authoridSahin, Gulizar/0000-0002-0409-2710
dc.authoridGursu, Meltem/0000-0003-3972-2521
dc.authoridMirioglu, Safak/0000-0003-0362-8154
dc.authoridCetinkaya, Hakki/0000-0001-9527-3885
dc.authoridATILGAN, KADIR GOKHAN/0000-0001-9905-4305
dc.authoridEren, Necmi/0000-0002-2708-3470
dc.authoridYazici, Halil/0000-0003-2526-3483
dc.authorwosidATILGAN, KADIR GOKHAN/AAQ-5094-2020
dc.contributor.authorCetinkaya, Hakki
dc.contributor.authorGursu, Meltem
dc.contributor.authorYazici, Halil
dc.contributor.authorCebeci, Egemen
dc.contributor.authorEren, Necmi
dc.contributor.authorAltiparmak, Mehmet Riza
dc.contributor.authorAkcay, Omer Faruk
dc.date.accessioned2024-06-12T11:03:39Z
dc.date.available2024-06-12T11:03:39Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Immunoglobulin A nephropathy (IgAN) is a common primary glomerulonephropathy. There is evidence that mesangial C3 deposition plays a role in the development of the disease. The aim of this study was to examine the effect of C3 deposition on the prognosis of IgAN patients.Method: The study included 1135 patients with biopsy-confirmed IgAN from the database of the Turkish Nephrology Association Glomerular Diseases Working Group (TSN-GOLD). Patients were excluded from the study if they were aged < 18 or > 75 years or if C3 staining had not been performed in the immunofluorescent analysis. C3 deposition was defined as an immunofluorescence intensity of C3 >= 2 + within the mesangium. The primary endpoints were the development of end-stage renal disease, a 30% decrease in glomerular filtration rate compared to the basal value or an elevation in proteinuria to a nephrotic level (3.5 gr/day).Results: Mesangial C3 deposition was observed in 603 (53.1%) patients. No statistically significant difference was found at baseline between the groups with and without mesangial C3 deposition, as for age, sex, BMI, proteinuria level, or the presence of hypertension. In the follow-up period with a mean duration of 78 months, no significant difference was found between the two groups regarding the primary endpoints (p = 0.43). A significant correlation between C3 deposition and segmental glomerulosclerosis (S1) according to the Oxford MEST-C classification was found (p = 0.001).Conclusion: Although a correlation was observed between mesangial C3 deposition and the S1 MEST-C classification, mesangial C3 deposition was not a prognostic factor in IgAN.en_US
dc.description.sponsorshipWe would like to express our endless thanks to the Turkish Society of Nephrology, who organized the background of the study, and to the pathologists in each centre for their contributions to patient care and their help in providing these data.en_US
dc.description.sponsorshipWe would like to express our endless thanks to the Turkish Society of Nephrology, who organized the background of the study, and to the pathologists in each centre for their contributions to patient care and their help in providing these data.en_US
dc.identifier.doi10.1007/s40620-023-01770-1
dc.identifier.issn1121-8428
dc.identifier.issn1724-6059
dc.identifier.pmid37947938en_US
dc.identifier.scopus2-s2.0-85176146454en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s40620-023-01770-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21745
dc.identifier.wosWOS:001106687900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal Of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIga Nephropathyen_US
dc.subjectComplementen_US
dc.subjectC3 Depositionen_US
dc.subjectOxford Classificationen_US
dc.subjectIga Nephropathyen_US
dc.subjectOxford Classificationen_US
dc.subjectValidationen_US
dc.titleCould mesangial C3 deposition be an independent prognostic marker in immunoglobulin A nephropathy?en_US
dc.typeArticleen_US

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