Effects of sphingosylphosphorylcholine against oxidative stress and acute lung injury induced by pulmonary contusion in rats

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dc.authoridKARACA, Turan/0000-0002-2500-7781;
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.authorwosidAyaz, Ahmet/I-9910-2019
dc.contributor.authorAksu, Burhan
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorAksu, Feyza
dc.contributor.authorKaraca, Turan
dc.contributor.authorCemek, Mustafa
dc.contributor.authorAyaz, Ahmet
dc.contributor.authorDemirtas, Selim
dc.date.accessioned2024-06-12T11:15:26Z
dc.date.available2024-06-12T11:15:26Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/purpose: The goal of this study was to evaluate effects of exogenous sphingosylphosphorylcholine (SPC) administration on acute lung injury induced by pulmonary contusion in rats. Methods: Eight animals were included in each of the following five groups: control, contusion, contusion phosphate-buffered solution (PBS), contusion SPC 2, contusion SPC 10. SPC was administered 3 days at a daily two different doses of 2 mu m/ml and 10 mu m/ml intraperitoneally. The severity of lung injury was determined by the neutrophil activation and histological and immunohistochemical changes in the lung. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione (GSH) were determined to evaluate the oxidative status in the lung tissue. Results: Treatment with 2 mu M SPC inhibited the increase in lung MDA and NO levels significantly and also attenuated the depletion of SOD, GPx, and GSH in the lung injury induced by pulmonary contusion. These data were supported by histopathological findings. The inducible nitric oxide synthase (iNOS) positive cells and apoptotic cells in the lung tissue were observed to be reduced with the 2 mu M SPC treatment. But, the 10 mu M SPC treatment did not provide similar effects. Conclusions: In conclusion, these findings suggested that 2 mu M SPC can attenuate lung damage in pulmonary contusion by prevention of oxidative stress, inflammatory process and apoptosis. All these findings suggest that low dose SPC may be a promising new therapeutic agent for acute lung injury. (C) 2015 Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.jpedsurg.2014.06.007
dc.identifier.endpage597en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue4en_US
dc.identifier.pmid25840069en_US
dc.identifier.scopus2-s2.0-84964241062en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage591en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2014.06.007
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23933
dc.identifier.volume50en_US
dc.identifier.wosWOS:000352140500019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSPCen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectPulmonary Contusionen_US
dc.subjectOxidative Stressen_US
dc.subjectLipid Peroxidationen_US
dc.subjectNitric Oxideen_US
dc.subjectBlunt Chest Traumaen_US
dc.subjectProtein-Kinase-Cen_US
dc.subjectSmooth-Muscle Contractionen_US
dc.subjectEndothelial-Cellsen_US
dc.subjectNitric-Oxideen_US
dc.subjectApoptosisen_US
dc.subjectModelen_US
dc.subjectSphingosine-1-Phosphateen_US
dc.subjectInvolvementen_US
dc.subjectGlutathioneen_US
dc.titleEffects of sphingosylphosphorylcholine against oxidative stress and acute lung injury induced by pulmonary contusion in ratsen_US
dc.typeArticleen_US

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