Preventive effects of quercetin against inflammation and apoptosis in cyclophosphamide-induced testicular damage

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dc.authoridUz, Yesim/0000-0002-0381-4590
dc.contributor.authorUzun-Goren, Duygu
dc.contributor.authorUz, Yesim Hulya
dc.date.accessioned2024-06-12T10:52:27Z
dc.date.available2024-06-12T10:52:27Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective(s): We aimed to investigate the effects of quercetin (QRC) against cyclophosphamide (CP)induced testicular damage and how it interacts with apoptotic and inflammatory signaling pathways. Materials and Methods: Forty male Wistar rats were randomly divided into four groups, 10 in each group; Control group (corn oil, intragastrically, 14 days), QRC group (100 mg/kg QRC, dissolved in corn oil, 14 days), CP group (200 mg/kg CP, intraperitoneally, single dose on the 7th day), and CP+QRC group (100 mg/kg QRC, intragastrically, 14 days and 200 mg/kg CP, intraperitoneally, single dose on the 7th day). Animals were sacrificed one day after the last QRC application and the effects of quercetin were evaluated by histological, morphometrical, and hormonal parameters. Also, nuclear factor kappa B (NFkB), nuclear factor erythroid 2 related factor 2 (Nrf2), Bcl-2 associated X protein (Bax), and B -cell lymphoma -2 (Bcl-2) immunoreactivities were evaluated immunohistochemically. Results: CP increased the testicular weight/body weight ratio, significantly decreasing body weights and testicular weights. All hormone levels were also reduced significantly. Morphometrically, seminiferous tubules diameter and germinal epithelial thickness decreased, while a significant increase was determined in interstitial field width in addition to histological damage. Furthermore, immunohistochemical findings also indicated that NFkB and Bax immunoreactivity were increased in the CP group, whereas significant decrease was seen in Nrf2 and Bcl-2 immunoreactivity. Apoptotic cell and tubule index were reduced in CP. QRC ensured improvement in all findings. Conclusion: Data showed us, that QRC may have preventive effects in CP -induced testicular damage by acting on NFkB, Nrf2, Bax, and Bcl-2 pathways.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Trakya University, Turkey [TUBAP 2017/79]en_US
dc.description.sponsorshipThis study was funded by Scientific Research Projects Coordination Unit of Trakya University, Turkey (Project number: TUBAP 2017/79) . The results described in this paper were part of PhD student thesis.en_US
dc.identifier.doi10.22038/IJBMS.2024.74458.16177
dc.identifier.endpage656en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue5en_US
dc.identifier.pmid38629094en_US
dc.identifier.scopus2-s2.0-85187650077en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage647en_US
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2024.74458.16177
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18689
dc.identifier.volume27en_US
dc.identifier.wosWOS:001182221900009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCyclophosphamideen_US
dc.subjectCyclophosphamide Inflammationen_US
dc.subjectQuercetinen_US
dc.subjectTestisen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectInduced Oxidative Injuryen_US
dc.subjectOxide Nanoparticlesen_US
dc.subjectReproductive-Systemen_US
dc.subjectStressen_US
dc.subjectToxicityen_US
dc.subjectProtectsen_US
dc.subjectDysfunctionen_US
dc.subjectExpressionen_US
dc.subjectExtracten_US
dc.titlePreventive effects of quercetin against inflammation and apoptosis in cyclophosphamide-induced testicular damageen_US
dc.typeArticleen_US

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