Exogenous L-Arginine and HDL Can Alter LDL and ox-LDL-Mediated Platelet Activation: Using Platelet P-Selectin Receptor Numbers

Basit Öğe Kaydı
dc.authoridYanikkaya Demirel, GULDEREN/0000-0001-5775-491X
dc.authoridVANIZOR KURAL, Birgul/0000-0003-0730-9660
dc.authorwosidYanikkaya Demirel, GULDEREN/I-2288-2018
dc.contributor.authorSener, Azize
dc.contributor.authorEnc, Elif
dc.contributor.authorOzsavci, Derya
dc.contributor.authorVanizor-Kural, Birgul
dc.contributor.authorYanikkaya-Demirel, Gulderen
dc.contributor.authorOba, Rabia
dc.contributor.authorUras, Fikriye
dc.date.accessioned2024-06-12T11:09:13Z
dc.date.available2024-06-12T11:09:13Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the effects of exogenous L-arginine and HDL on LDL and oxidized LDL (ox-LDL)-mediated platelet activation. Adenosine diphosphate (ADP)-activated platelets have been incubated with lipoproteins with or without L-arginine. P-selectin receptor numbers per platelet have been measured by flow cytometry. After incubation with only L-arginine (without lipoproteins), platelet nitric oxide (NO) levels and P-selectin receptor numbers significantly increased compared to the controls (P < .05). After incubation with LDL or ox-LDL, receptor numbers of P-selectin significantly increased (P < .001). However, P-selectin receptor numbers in platelets treated with L-arginine + LDL or L-arginine + ox-LDL decreased compared to the levels in platelets treated with only LDL or ox-LDL (P < .01, P < .001, respectively). Addition of HDL to L-arginine + ox-LDL caused significant reduction in P-selectin receptor numbers as in the control values (P < .001). We have concluded that L-arginine causes enhanced platelet NO levels and blocks the effects of LDL or ox-LDL on platelet P-selectin receptor numbers and HDL also strengthens this effect of L-arginine.en_US
dc.description.sponsorshipMarmara University Research Unit [SAG 070/060904]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: Supported in part by Marmara University Research Unit Grants SAG 070/060904.en_US
dc.identifier.doi10.1177/1076029610385223
dc.identifier.endpageE86en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue6en_US
dc.identifier.pmid21078607en_US
dc.identifier.scopus2-s2.0-84857214597en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE79en_US
dc.identifier.urihttps://doi.org/10.1177/1076029610385223
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22731
dc.identifier.volume17en_US
dc.identifier.wosWOS:000300376400016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitric Oxideen_US
dc.subjectLow-Density Lipoproteinen_US
dc.subjectHigh Density Lipoproteinen_US
dc.subjectOxidized Low-Density Lipoproteinen_US
dc.subjectPlateleten_US
dc.subjectL-Arginineen_US
dc.subjectP-Selectinen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectLow-Density-Lipoproteinen_US
dc.subjectOxidized-Ldlen_US
dc.subjectExpressionen_US
dc.subjectRisken_US
dc.subjectAtherosclerosisen_US
dc.subjectAggregationen_US
dc.subjectParaoxonaseen_US
dc.subjectLeukocyteen_US
dc.subjectTransporten_US
dc.titleExogenous L-Arginine and HDL Can Alter LDL and ox-LDL-Mediated Platelet Activation: Using Platelet P-Selectin Receptor Numbersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu