The effects of epidermal growth factor on early burn-wound progression in rats

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dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridOrhan, Abdullah Erkan/0000-0001-6532-5840
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidOrhan, Abdullah Erkan/A-6237-2017
dc.contributor.authorKaya, Oktay
dc.contributor.authorOrhan, Erkan
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorGunduz, Ozguer
dc.contributor.authorAydin, Bilgehan
dc.date.accessioned2024-06-12T10:55:26Z
dc.date.available2024-06-12T10:55:26Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAfter burns, protecting tissues by medicines in the zone of stasis reduces the width and depth of injury. This study's goal was to reduce burned tissue damage in the zone of stasis using epidermal growth factor (EGF). Forty-eight Wistar rats were separated into three groups. In all groups, the burn procedure was applied following the comb burn model. In Group 1, no postburn treatment was administered. In Group 2, physiological saline solution (0.3 cc) was injected intradermally and in Group 3, EGF (0.3 cc) was injected intradermally into stasis zone tissues after the burn procedure. Surviving tissue rates were 24.0% in Group 1, 25.3% in Group 2, and 70.2% in Group 3. The average numbers of cells stained with Nrf2, HO-1, and the number of apoptotic cells were 230, 150, and 17.5 in Group 1, 230, 145, and 15.0 in Group 2, and 370, 230, and 0 in Group 3, respectively. Values in Group 3 were found to be statistically significantly different than those of Groups 1 and 2; there was no difference between Groups 1 and 2. This study shows that EGF protects zone of stasis tissue from burn damage.en_US
dc.identifier.doi10.1111/dth.13196
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue1en_US
dc.identifier.pmid31849151en_US
dc.identifier.scopus2-s2.0-85076894333en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.13196
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19414
dc.identifier.volume33en_US
dc.identifier.wosWOS:000503920400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBurnen_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectZone Of Stasisen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectStromal-Vascular Fractionen_US
dc.subjectStem-Cellsen_US
dc.subjectEgfen_US
dc.subjectStasisen_US
dc.subjectZoneen_US
dc.subjectProliferationen_US
dc.subjectRegenerationen_US
dc.subjectActivationen_US
dc.titleThe effects of epidermal growth factor on early burn-wound progression in ratsen_US
dc.typeArticleen_US

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