Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis

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dc.authoridALIBAZ-ONER, FATMA/0000-0002-6653-1758
dc.authoridYolbaş, Servet/0000-0001-8516-9769
dc.authoridDemiryurek, Abdullah/0000-0003-4762-4745
dc.authorwosidDireskeneli, Haner/AAS-5508-2020
dc.authorwosidpehlivan, yavuz/AAG-8227-2021
dc.authorwosidALIBAZ-ONER, FATMA/AAR-2072-2020
dc.authorwosidYolbaş, Servet/ABI-5312-2020
dc.authorwosidDemiryurek, Abdullah/AAG-5244-2020
dc.contributor.authorPehlivan, Yavuz
dc.contributor.authorYolbas, Servet
dc.contributor.authorCetin, Gozde Yildirim
dc.contributor.authorAlibaz-Oner, Fatma
dc.contributor.authorCagatay, Yonca
dc.contributor.authorYilmaz, Neslihan
dc.contributor.authorOztuzcu, Serdar
dc.date.accessioned2024-06-12T11:15:57Z
dc.date.available2024-06-12T11:15:57Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSystemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathogenesis of fibrosis, inflammation and vascular abnormalities. This study was aimed to investigate the relation between SSc and Rho/Rho-kinase gene polymorphisms. The study included 339 patients with SSc and 302 healthy subjects who were apparently healthy and at similar age and gender. Genotype distributions and allele frequencies were detected by using Chi-square test or Fisher's exact Chi-square test between groups, and the haplotype analysis was applied using online program (SHEsis). Significant association was found in a polymorphism in the ROCK1 gene (rs35996865), a polymorphism in ROCK2 gene (rs10178332), a polymorphism in RhoA gene (rs2177268) and two polymorphisms in RhoC gene (rs11102522 and rs11538960) with SSc disease (p < 0.0022). In this study, association between SSc disease and Rho/Rho-kinase gene polymorphisms was investigated for the first time; significant associations between ROCK1, ROCK2, RhoA and RhoC gene polymorphisms and SSc disease were demonstrated. The results strongly suggest that this SNP may be an important risk factor for development of SSc. However, further validation of these findings in an independent cohort is necessary.en_US
dc.description.sponsorshipUniversity of Gaziantep [BAP TF.12.16]en_US
dc.description.sponsorshipThis project was supported by a project (BAP TF.12.16) from the University of Gaziantep.en_US
dc.identifier.doi10.1007/s00296-015-3400-4
dc.identifier.endpage427en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue3en_US
dc.identifier.pmid26615410en_US
dc.identifier.startpage421en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-015-3400-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24141
dc.identifier.volume36en_US
dc.identifier.wosWOS:000374566000014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSystemic Sclerosisen_US
dc.subjectPathogenesisen_US
dc.subjectRho/Rho-Kinaseen_US
dc.subjectEarly Diagnosisen_US
dc.subjectRho-Kinaseen_US
dc.subjectUrotensin-Iien_US
dc.subjectPulmonary-Hypertensionen_US
dc.subjectEndothelinen_US
dc.subjectReceptoren_US
dc.subjectSclerodermaen_US
dc.subjectFibrosisen_US
dc.subjectDifferentiationen_US
dc.subjectVasoconstrictoren_US
dc.subjectInhibitionen_US
dc.titleInvestigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosisen_US
dc.typeArticleen_US

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