ANTIEMETIC EFFICACY OF DIAZEPAM IN THE PROPHYLAXIS OF ACUTE AND DELAYED EMESIS INDUCED BY CISPLATIN BASED CHEMOTHERAPY TREATED WITH STANDARD ANTI EMETICS

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dc.authorwosidSaip, pınar/AAT-1500-2020
dc.authorwosidBasaran, Mert/AAT-7762-2020
dc.authorwosidUygun, Kazim/AFL-7917-2022
dc.authorwosidUygun, Kazim/AAG-7880-2022
dc.contributor.authorSaip, Pinar
dc.contributor.authorOnat, Haluk
dc.contributor.authorUygun, Kazim
dc.contributor.authorDemir, Cumhur
dc.contributor.authorSalepci, Taflan
dc.contributor.authorGuney, Nese
dc.contributor.authorBasaran, Mert
dc.date.accessioned2024-06-12T11:00:17Z
dc.date.available2024-06-12T11:00:17Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study was conducted to evaluate the efficacy of diazepam in managing acute and delayed emesis induced by cisplatin-based chemotherapy. A total of 92 cancer patients who were receiving 60-75 mg/m(2) cisplatin based chemotherapy were treated with granisetron 3 mg/IV plus dexamethasone 16 mg/IV on the first day of the chemotherapy Forty three of these patients also treated with diazepam 5 mg/PO 10-12 and 1 hours before the chemotherapy and 42 of these patients did not received any diazepam prophylaxis. Categorical scales were utilised to document the incidence of vomiting, nausea and loss of appetite. Among the 85 evaluable patients there was no statistically significant difference between the treatment arms in terms of acute and delayed emesis. But more patients achieved acute complete control of vomiting (79% vs 64%) and defined their quality of life as very good and good (70% vs 52%) in the diazepam arm. The protection obtained at the first day significantly influenced the protection during the subsequent days irrespective of the treatment arms. Diazepam does not increase the efficacy of antiemetic treatment but the increase in the patients well being and complete control acute vomiting suggest that it could be added to the standard antiemetic protocols.en_US
dc.identifier.endpage+en_US
dc.identifier.issn1300-7467
dc.identifier.issue2en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20780
dc.identifier.volume20en_US
dc.identifier.wosWOS:000439247600003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEmesisen_US
dc.subjectCisplatinen_US
dc.subjectDiazepamen_US
dc.subjectPlus Dexamethasoneen_US
dc.subjectMetoclopramideen_US
dc.subjectRegimensen_US
dc.subjectNauseaen_US
dc.titleANTIEMETIC EFFICACY OF DIAZEPAM IN THE PROPHYLAXIS OF ACUTE AND DELAYED EMESIS INDUCED BY CISPLATIN BASED CHEMOTHERAPY TREATED WITH STANDARD ANTI EMETICSen_US
dc.typeArticleen_US

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