Therapeutic plasma exchange in patients with neurologic diseases: Retrospective multicenter study

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dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridCETIN, Mustafa/0000-0003-4512-1124
dc.authoridKaynar, Leylagul/0000-0002-2035-9462
dc.authoridAltuntas, Fevzi/0000-0001-6872-3780
dc.authoridKOCYIGIT, ISMAIL/0000-0002-6654-4727
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidCETIN, Mustafa/B-3607-2015
dc.authorwosidKaynar, Leylagul/F-6991-2013
dc.authorwosidISMAILOGULLARI, SEVDA/B-2754-2018
dc.authorwosid, aliunal/GLQ-6094-2022
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.authorwosidAltuntas, Fevzi/E-8945-2015
dc.contributor.authorKaynar, Leylagul
dc.contributor.authorAltuntas, Fevzi
dc.contributor.authorAydogdu, Ismet
dc.contributor.authorTurgut, Burhan
dc.contributor.authorKocyigit, Ismail
dc.contributor.authorHacioglu, Sibel Kabukcu
dc.contributor.authorIsmailogullari, Sevda
dc.date.accessioned2024-06-12T11:16:13Z
dc.date.available2024-06-12T11:16:13Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTherapeutic plasma exchange (TPE) is commonly used in many neurological disorders where an immune etiology was known or suspected. We report our experience with TPE performed for neuroimmunologic disorders at four university hospitals. The study was a retrospective review of the medical records of neurological patients (n = 57) consecutively treated with TPE between April 2006 and May 2007. TPE indications in neurological diseases included Guillain-Barre Syndrome (GBS) (n = 41), myasthenia gravis (MG) (n = 11), acute disseminated encephalomyelitis (ADEM) (n = 3), chronic inflammatory demyelinating polyneuropathy (CIDP) (n = 1) and multiple sclerosis (MS) (n 1). Patient median age was 49; there was a predominance of males. Twenty-two patients had a history of other therapy including intravenous immunoglobulin (IVIG), steroid, azothioprin, and pridostigmine prior to TPE. Another 35 patients had not received any treatment prior to TPE. All patients were classified according to the Hughes functional grading scores pre- and first day post-TPE for early clinical evaluation of patients. The TPE was carried out 1-1.5 times at the predicted plasma volume every other day. Two hundred and ninety-four procedures were performed on 57 patients. The median number of TPE sessions per patient was five, and the median processed plasma volume was 3075 mL for each cycle. Although the pre-TPE median Hughes score of all patients was 4, it had decreased to grade I after TPE. While the pre-TPE median Hughes score for GBS and MG patients was 4, post-TPE scores were decreased to grade 1. Additionally, there was a statistically significant difference between post-TPE Hughes score for GBS patients with TPE as front line therapy and patients receiving IVIG as front line therapy (1 vs. 3.5; p = 0.034). Although there was no post-TPE improvement in Hughes scores in patients with ADEM and CIDP, patients with MS had an improved Hughes score from 4 to 1. Mild and manageable complications such as hypotension and hypocalcemia were also observed. TPE may be preferable for controlling symptoms of neuroimmunological disorders in early stage of the disease, especially with GBS. (C) 2008 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.transci.2007.11.002
dc.identifier.endpage115en_US
dc.identifier.issn1473-0502
dc.identifier.issue2en_US
dc.identifier.pmid18331814en_US
dc.identifier.scopus2-s2.0-42649095636en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2007.11.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24236
dc.identifier.volume38en_US
dc.identifier.wosWOS:000256336800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion And Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTherapeutic Plasma Exchangeen_US
dc.subjectGuillain-Barr Syndrome (GBS)en_US
dc.subjectMyasthenia Gravis (MG)en_US
dc.subjectAcute Disseminated Encephalomyelitis (ADEM)en_US
dc.subjectChronic Inflammatory Demyelinating Polyneuropathy (CIDP)en_US
dc.subjectMultiple Sclerosis (MS)en_US
dc.subjectNeuroimmunological Disordersen_US
dc.subjectTrialen_US
dc.subjectComplicationsen_US
dc.subjectExperienceen_US
dc.subjectApheresisen_US
dc.titleTherapeutic plasma exchange in patients with neurologic diseases: Retrospective multicenter studyen_US
dc.typeArticleen_US

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