Gastric damage related to radioactive iodine treatment and the protective effect of amifostine

Basit Öğe Kaydı
dc.authorscopusid24598133700
dc.authorscopusid56735615100
dc.authorscopusid20735640800
dc.authorscopusid55929946400
dc.contributor.authorSezer A.
dc.contributor.authorCelik M.
dc.contributor.authorUsta U.
dc.contributor.authorAltun G.D.
dc.date.accessioned2024-06-12T10:29:22Z
dc.date.available2024-06-12T10:29:22Z
dc.date.issued2017
dc.description.abstractIntroduction: The aim of this study was to evaluate the gastric damage related to high dose radioactive iodine treatment during thyroid cancer treatment in an experimental rat model and evaluate histopathologically the radioprotective effect of amifostine. Methods and findings: 40 adult rats were enrolled into the study. Radioactive iodine treatment with 30 mCi/kg I131 was applied via orogastric tube simulating radioiodine ablation treatment (RAI) in thyroid cancer in all rats. After RAI subjects were divided into 2 groups: Group Orogastric RAI (Group OG, n: 20): Rats received no radioprotective agent but serum physiologic. Group Amifostine RAI (Group AP, n: 20): Rats received 200 mg/kg amifostine intraperitoneally 30 minutes before I131 application. On the 1st, 3rd, 5th and 7th days of experiment rats were sacrificed for histopathological evaluation. Gastric tissues were excised and tissue damage was assessed by using histopathological scoring. Total pathology score revealed a significant change on the 7th day. The subjects in Group OG had histopathological changes, while only one subject in Group AP was found to have pathologic changes (X2=39.7 df (28), p=0.04). The common histopathological findings were striking mucosal and intraepithelial leucocytic infiltration together with thinning of the mucosa, regenerative changes, and reactive atypia. Conclusions: RAI treatment causes gastric mucosal injury and amifostine was found to decrease radioactive iodine treatment related gastric damage. © 2017, Scientific Publishers of India. All rights reserved.en_US
dc.identifier.endpage3710en_US
dc.identifier.issn0970-938X
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85019573835en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3705en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17724
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers of Indiaen_US
dc.relation.ispartofBiomedical Research (India)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostine; Gastric Damage; Radioactive Iodine Treatment; Thyroiden_US
dc.subjectAmifostine; Radioactive Iodine; Ablation Therapy; Adult; Animal Experiment; Animal Model; Animal Tissue; Article; Blood Analysis; Cell Regeneration; Controlled Study; Drug Effect; Histopathology; Lymphocytic Infiltration; Mouth Mucosa; Nonhuman; Rat; Scoring System; Stomach Injury; Stomach Protection; Thyroid Cancer; Tissue Regenerationen_US
dc.titleGastric damage related to radioactive iodine treatment and the protective effect of amifostineen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu