Protective effects of L-carnitine and alpha-lipoic acid in rats with adjuvant arthritis

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorTastekin, Nurettin
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorUsta, Ufuk
dc.contributor.authorBirtane, Murat
dc.contributor.authorErbas, Hakain
dc.contributor.authorTure, Mevlut
dc.date.accessioned2024-06-12T10:50:46Z
dc.date.available2024-06-12T10:50:46Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFree radicals play an important role in the pathophysiology of adjuvant arthritis. The purpose of this study was to assess the efficacy Of L-carnitine (LC) and alpha-lipoic acid (alpha-LA) which are known to have antioxidant effects, in the treatment of adjuvant arthritis. Arthritis model was created by the administration of complete Freund's adjuvant (CFA) in 32 of 40 male Sprague-Dawley rats. The rats were divided into five groups. Rats in Group I served as controls and received 0.1 ml kg(-1) saline. Group II received only 0.1 ml of CFA and served as the CFA-control for the other groups. Groups III-V, after being injected with CFA, were treated with LC, alpha-LA or diclofenac, respectively. Levels of malondialdehyde (MDA) and glutathione (GSH) were measured in plasma samples. Enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured. The paws of rats were evaluated histopathologically to investigate the anti-inflammatory effects. TNF-alpha levels were measured for the evaluation of inflammation. In G roup II plasma MDA increased, levels of glutathione decreased, enzymeactivities of SOD and GPx decreased. Histopathological damage increased in the paws of the rats in this group. MDA levels decreased in Groups III-V when compared with Group II. GSH levels significantly increased in Group III and IV than Group V. SOD activity of Group IV was higher than Group III and V. TNF-alpha levels were significantly lower in Group IV and V. LC and a-LA seemed to have protective effects against oxidative damage in adjuvant arthritis model. (c) 2007 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.phrs.2007.07.008
dc.identifier.endpage310en_US
dc.identifier.issn1043-6618
dc.identifier.issue4en_US
dc.identifier.pmid17826175en_US
dc.identifier.scopus2-s2.0-34748921578en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2007.07.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18107
dc.identifier.volume56en_US
dc.identifier.wosWOS:000250617100004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdjuvant Arthritisen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.subjectAntioxidanten_US
dc.subjectL-Carnitineen_US
dc.subjectLipid Peroxidationen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectFree-Radicalsen_US
dc.subjectAntioxidantsen_US
dc.subjectInflammationen_US
dc.subjectGlutathioneen_US
dc.subjectOxidationen_US
dc.subjectCollagenen_US
dc.subjectMarkersen_US
dc.subjectStressen_US
dc.titleProtective effects of L-carnitine and alpha-lipoic acid in rats with adjuvant arthritisen_US
dc.typeArticleen_US

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