The Effects of Taurine, Melatonin and N-Acetylcystein on Cadmium Exposure Bone Changes The Surprising Effect of Taurine

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dc.authoridErem, Murat/0000-0002-9743-5515
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.authorwosidErem, Murat/P-6240-2018
dc.contributor.authorTastekin, Nurettin
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorAltun, Gulay Durmus
dc.contributor.authorErbas, Hakan
dc.contributor.authorUzunca, Kaan
dc.contributor.authorBirtane, Murat
dc.contributor.authorKaplan, Mustafa
dc.date.accessioned2024-06-12T10:55:27Z
dc.date.available2024-06-12T10:55:27Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Chronic environmental and occupational exposure to cadmium can result in skeletal system changes. The main objective of the present study was to investigate and compare the effects of taurine, melatonin and N-acetyl cysteine on cadmium exposure induced bone density loss. Methods: 90 adult male Sprague-Dawley rats were allocated into four main groups: Group I was the control group; Group II was the cadmium exposure group; Group 3 was cadmium exposure for 3 months + concurrent antioxidant administration group. The concept of Group 4 was cadmium exposure for 3 months + subsequent antioxidant administration. Bone mineral density values were evaluated in all the groups. Serum calcium, phosphorus, alkaline phosphatase (ALP) enzyme activities and 24 hours urine calcium excretion levels were measured. Kruskal-Wallis test was used to compare the all groups. Between two group comparisons, the Mann-Whitney U test was used. Results: There was no significant difference in terms of bone mineral density values only between control group and cadmium exposure group (p 0.05). Mean bone mineral density values obtained in cadmium + concurrent taurine and cadmium + subsequent taurine groups were significantly lower than all the other groups (p<0.05). 24 hours urine calcium excretion levels were significantly higher in groups which taurine and n-asetylcystein were administered after cadmium exposure. Conclusion: Taurine, which is thought to have protective effects as an antioxidant caused a marked bone damage after exposure to cadmium. Further studies are needed to clarify this effect of taurine.en_US
dc.identifier.doi10.12996/gmj.2020.129
dc.identifier.endpage552en_US
dc.identifier.issn2147-2092
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85091852826en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage549en_US
dc.identifier.urihttps://doi.org/10.12996/gmj.2020.129
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19430
dc.identifier.volume31en_US
dc.identifier.wosWOS:000573105000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGazi Univ, Fac Meden_US
dc.relation.ispartofGazi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCadmium Exposureen_US
dc.subjectTaurineen_US
dc.subjectN-Asetylcysteinen_US
dc.subjectBoneen_US
dc.subjectAntioxidanten_US
dc.subjectMelatoninen_US
dc.subjectMineral Densityen_US
dc.subjectDamageen_US
dc.subjectSupplementationen_US
dc.subjectOxygenen_US
dc.subjectLevelen_US
dc.titleThe Effects of Taurine, Melatonin and N-Acetylcystein on Cadmium Exposure Bone Changes The Surprising Effect of Taurineen_US
dc.typeArticleen_US

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