Evaluation of Risk Factors in Community-Acquired Urinary Tract Infections Caused by Extended Spectrum ?-Lactamase-Producing Escherichia coli

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dc.authorwosidErtan, Asli/AAE-6201-2021
dc.contributor.authorKara, Mehmet
dc.contributor.authorElmaslar-Mert, Habibe Tulin
dc.contributor.authorKuloglu, Figen
dc.contributor.authorAkata, Filiz
dc.date.accessioned2024-06-12T11:01:29Z
dc.date.available2024-06-12T11:01:29Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The objective of this study was to determine the risk factors in community -acquired urinary tract infections (UTIs) caused by extended spectrum 13-lactanriase (ESBL)producing Escherichia coli, and antibiotic resistance rates in these strains. Methods: Patients who had been admitted to the Trakya University Health Center for Medical Research and Practice Infectious Diseases and Clinical Microbiology Department with the diagnosis of UTI from January 1, 2008 through January 1, 2018 and had F. coli growth in urine culture were analyzed retrospectively. Patients who had ESBL-positive E. coil growth in their urine cultures were the case group and patients with the ESBL-negative E. coli growth in their urine cultures were the control group. Results: In the study, 379 UTI episodes were detected in 346 patients. There were 117 (30.9%) episodes in the case group and 262 (69.1%) episodes in the control group. In univariate analysis, young age (approximately 62 19.6 years in the case group, 68 19.4 years in the control group), malignancy in a solid organ, urinary pathologies, urinary catheterization, history of urological procedure in the last six months, history of hospitalization in the last three months, history of antibiotic use in the last three months and recurrent UTI were statistically significant for ESBL production (p<0.05). In multivariate analysis, malignancy in a solid organ (OR: 2.267; CI: 1.205-4.266; p=0.011), urinary catheterization (OR: 2.266; CI: 1.186-4.330; p=0.013), and antibiotic use in the last three months (OR: 5.050; CI: 3.038-8.395; p=0.000) were found to be the independent risk factors for ESBL production. Empirical treatment effectiveness rate was lower and hospital stay was longer in the case group. F. coli strains were found to have higher resistance rates to antibiotics other than fosfomycin and nitrofurantoin and they were not suitable for empirical treatment of UTIs. Conclusions: Knowing the risk factors and antibiotic resistance rates in terms of ESBL production in the community patients will both increase the empirical treatment success of UTIs and reduce unnecessary antibiotic use.en_US
dc.identifier.doi10.5152/kd.2020.11
dc.identifier.endpage61en_US
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85088746272en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.5152/kd.2020.11
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20902
dc.identifier.volume33en_US
dc.identifier.wosWOS:000531866700012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherDoc Design Informatics Co Ltden_US
dc.relation.ispartofKlimik Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEscherichia Colien_US
dc.subjectExtended Spectrum Beta-Lactamasesen_US
dc.subjectUrinary Tract Infectionsen_US
dc.subjectRisk Factorsen_US
dc.subjectEpidemiologyen_US
dc.subjectEnterobacteriaceaeen_US
dc.subjectPyelonephritisen_US
dc.subjectGuidelinesen_US
dc.subjectOrganismsen_US
dc.subjectBacteriaen_US
dc.subjectAmericaen_US
dc.subjectImpacten_US
dc.titleEvaluation of Risk Factors in Community-Acquired Urinary Tract Infections Caused by Extended Spectrum ?-Lactamase-Producing Escherichia colien_US
dc.typeArticleen_US

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