Investigation of the effects of ellagic, vanillic and rosmarinic acid on reperfusion-induced renal injury

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dc.contributor.authorGurmen, Alper
dc.contributor.authorGuclu, Orkut
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorCan, Nuray
dc.contributor.authorOzgun, Eray
dc.contributor.authorBuyukadali, Mursel
dc.contributor.authorReyhancan, Adem
dc.date.accessioned2024-06-12T11:07:16Z
dc.date.available2024-06-12T11:07:16Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: The aim of this study was to investigate the effects of ellagic, vanillic and rosmarinic acid on reperfusion-related kidney damage, developed in an experimental lower-extremity ischaemia/reperfusion (I/R) model.Methods: Forty-eight female Sprague-Dawley rats were divid-ed into six groups. A median laparotomy and dissection were performed. In the I/R group, 60 minutes of ischaemia followed by 120 minutes of reperfusion was achieved. In addi-tion one group was given 100 mg/kg ellagic acid, one group was given 12 mg/kg vanillic acid, one group was given 50 mg/ kg rosmarinic acid and one group was given all three drugs 15 minutes before clamp removal. Bilateral kidney and blood samples were taken in all groups.Results: Tubular epithelial degeneration, necrosis of the tubule epithelium and vessel wall thickening were significantly higher in the I/R group. Some parameters in the groups that were given drugs were found to be lower than in the I/R group and close to that of the control group. Total oxidant status (TOS) and oxidative stress index (OSI) were significantly higher and total antioxidant status (TAS) was significantly lower in the I/R group. Although not statistically significant in the groups given drugs, TAS was higher, and TOS and OSI were lower than in the I/R group.Conclusion: The antioxidant effect of ellagic, vanillic and rosmarinic acid administration may have beneficial effects on renal damage after reperfusion in acute lower-extremity ischaemia. This study is expected to provide information for future clinical trials.en_US
dc.description.sponsorshipTUBAP [2021/143]en_US
dc.description.sponsorshipThe study was supported by TUBAP (2021/143) .en_US
dc.identifier.doi10.5830/CVJA-2023-061
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.pmid38032731en_US
dc.identifier.urihttps://doi.org/10.5830/CVJA-2023-061
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21979
dc.identifier.wosWOS:001113398300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinics Cardive Publ Pty Ltden_US
dc.relation.ispartofCardiovascular Journal Of Africaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschaemia/Reperfusionen_US
dc.subjectRenal Injuryen_US
dc.subjectEllagic Aciden_US
dc.subjectVanillic Aciden_US
dc.subjectRosmarinic Aciden_US
dc.subjectOxidative Stressen_US
dc.subjectIschemiaen_US
dc.subjectHistopathologyen_US
dc.subjectLiveren_US
dc.titleInvestigation of the effects of ellagic, vanillic and rosmarinic acid on reperfusion-induced renal injuryen_US
dc.typeArticleen_US

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